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OpenTrials
Completed

NCT Number: NCT00233532

Canadian Study of Trandolapril on Blood Pressure in Hypertensive Patients (TRAIL)

The TRAIL study was conducted to examine the effects of escalating doses of an ACE inhibitor, trandolapril, on lowering blood pressure in Stage 1-2 hypertensive patients.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Stage 1 or 2 Hypertension

Exclusion criteria

  • Uncontrolled diabetes
  • Subject has a hypersensitivity to ACE inhibitor

Treatment and study plan

trandolapril

Drug

0.5, 1,2,4mg/once daily/ for 26 weeks (If BP was not controlled, dose was escalated to the next higher dosage every 4-5 weeks).

Other names: ABT-TARKA, trandolapril/verapamil, TARKA

Primary outcomes

  1. Effectiveness of escalating dose regimen of trandolapril in controlling blood pressure

    Time frame: 14 weeks

Secondary outcomes

  1. Changes in blood pressure, safety.

    Time frame: 14 and 26 weeks

  2. BP mmHg incremental and absolute change

    Time frame: 14 and 26 weeks

  3. Adverse events

    Time frame: Throughout 26 weeks

Sponsors and collaborators

Lead sponsor

Abbott

Industry

Registry information

Official study title

A Prospective, Open-Label Study to Evaluate the Effect of an Escalating Dose Regimen of Trandolapril on Blood Pressure in Treatment-Naïve and Concurrently Treated Hypertensive Patients (TRAIL)

Acronym: TRAIL

Important dates

Study start
2004
Primary completion
2005
First posted
Oct 6, 2005
Registry last updated
Jul 22, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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