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OpenTrials
Completed

NCT Number: NCT06765083

Can we 'Hear' Femoral Neck Fractures? Ultrasound Guided Diagnosis of Femoral Neck Fractures

Hip (femoral neck and pertrochanteric) fractures account for a significant part of Emergency Department (ED) visits after trauma. Studies suggest that point-of-care ultrasound (POCUS) is a reliable diagnostic tool for fracture assessment. POCUS has several advantages over conventional radiography, such as being portable, cheaper and radiation free. In addition, immediate conversion to ultrasound guided regional anaesthesia upon diagnosis of fracture can improve patient's time to proper analgesia. Moreover, POCUS can potentially be used pre-hospital to rule out hip fractures reducing ED crowding, as well as being a solution for areas where radiography is not readily available (e.g. rural or developing areas).

The primary objective of this study, is to evaluate the diagnostic capabilities of POCUS regarding patients with suspected hip fracture after trauma compared to radiography, the current standard of care diagnostic tool.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medisch Centrum Leeuwarden

Leeuwarden, 8934 AD, Netherlands

About this study

Rationale: Hip (femoral neck and pertrochanteric) fractures account for a significant part of Emergency Department (ED) visits after trauma. Studies suggest that point-of-care ultrasound (POCUS) is a reliable diagnostic tool for fracture assessment. POCUS has several advantages over conventional radiography, such as being portable, cheaper and radiation free. In addition, immediate conversion to ultrasound guided regional anaesthesia upon diagnosis of fracture can improve patient's time to proper analgesia. Moreover, POCUS can potentially be used pre-hospital to rule out hip fractures reducing ED crowding, as well as being a solution for areas where radiography is not readily available (e.g. rural or developing areas).

Objective: Our primary objective is to evaluate the diagnostic capabilities of POCUS regarding patients with suspected hip fracture after trauma compared to radiography, the current standard of care diagnostic tool.

Study design: Prospective cohort study. Study population: All patients aged 18 and older presenting to the ED with a painful hip after trauma suspected of hip fracture are eligible to be enrolled in this study.

Intervention: Patients enrolled in the study will undergo POCUS of the hip (femoral neck) by the (resident) emergency physician, prior to radiograph imaging.

Main study parameters/endpoints: Sensitivity, specificity, positive predicting value (PPV) and negative predicting value (NPV) of POCUS in detecting hip fractures by assessing for posttraumatic changes (cortical disruptions, joint effusion and peritrochanteric edema).

Informed consent will be requested and documented.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ≥18 years of age
  • presenting to the ED with a painful hip after trauma, suspected of hip fracture as defined by the attending clinician

Exclusion criteria

  • History of hip fracture or surgical procedure on the bones of the ipsilateral hip (ultrasound images may be unreliable)
  • Presence of foreign body material in the ipsilateral hip
  • Skin defects at the POCUS site e.g. lacerations, infected skin
  • Extensive injuries, extreme pain or neurovascular damage where urgent intervention is required
  • Inability to give informed consent (cognitive impairments, no proficient understanding of the Dutch or English language)

Treatment and study plan

POCUS of the hip

Diagnostic Test

POCUS of the hip (proximal femur) by the (resident) emergency physician, prior to radiograph imaging.

Primary outcomes

  1. Diagnostic accuracy of POCUS

    Time frame: From enrollment to the end of POCUS, approximately 10 to 30 minutes

    Diagnostic accuracy (sensitivity, specificity, negative predicting value (NPV) and positive predicting value (PPV)) of POCUS in detecting hip fractures by assessing for posttraumatic changes (cortical disruptions, joint effusion and peritrochanteric edema).

Secondary outcomes

  1. Difference in diagnostic accuracy of POCUS in diagnosing a femoral neck or pertrochanteric fracture

    Time frame: From enrollment to the end of POCUS, approximately 10 to 30 minutes

    Difference in diagnostic accuracy (sensitivity, specificity, negative predicting value (NPV) and positive predicting value (PPV)) of POCUS in diagnosing a femoral neck or pertrochanteric fracture

  2. Difference in diagnostic accuracy of POCUS in detecting hip fractures stratified by operator experience (in years) using POCUS

    Time frame: From enrollment to the end of POCUS, approximately 10 to 30 minutes

    Difference in diagnostic accuracy (sensitivity, specificity, negative predicting value (NPV) and positive predicting value (PPV)) of POCUS in detecting hip fractures stratified by operator experience (in years) using POCUS

  3. Difference in effusion measured in mm between the ipsilateral and contralateral hip

    Time frame: From enrollment to the end of POCUS, approximately 10 to 30 minutes

    Difference in effusion measured in mm between the ipsilateral and contralateral hip

  4. Added value of POCUS in detecting hip fractures compared to the likelihood determined through clinical assessment by the treating physician

    Time frame: From enrollment to the end of POCUS, approximately 10 to 30 minutes

    Evaluate the added value of POCUS in detecting hip fractures compared to the likelihood determined through clinical assessment by the treating physician (questionnaire: hip fracture clinical suspected yes or no)

Sponsors and collaborators

Lead sponsor

Frisius Medisch Centrum

Other

Registry information

Official study title

Can we 'Hear' Femoral Neck Fractures? Ultrasound Guided Diagnosis of Femoral Neck Fractures.

Acronym: CHEFF

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jan 9, 2025
Registry last updated
Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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