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Completed

NCT Number: NCT00317551

Cambridge Anti-Myopia Trial: Accommodation Training and Aberration Control in Myopia Development

We have identified focussing problems related to myopia getting worse. Our trial uses optical and orthoptic interventions that correct the focussing problems to see if this retards myopia progression.

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Key information

Conditions

Myopia Eye Diseases Refractive Errors

Age range

14 year–21 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Anglia Ruskin University

Cambridge, Cambridgeshire, CB1 1PT, United Kingdom

About this study

Myopia is a burgeoning health and social problem. Currently there is no acceptable clinical treatment that prevents progression. This study is a double masked placebo controlled block randomized clinical trial of two interventions, to treat accommodative factors we have identified as being significantly correlated to myopia progression (rather than to the presence of myopia). We have shown that the interventions normalise the accommodative factors, and this trial examines the effect of these interventions on myopia progression.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Best corrected visual acuity of 6/5 in each eye
  • Myopia in each meridian of at least 0.50 D
  • Willingness to give consent
  • Willingness to undertake any treatment option

Exclusion criteria

  • History of systemic/ocular pathology
  • History of any ocular surgery
  • More than 10D of myopia
  • Astigmatism more than 1.00 D

Treatment and study plan

Aberration controlled contact lens

Device

Vision training

Behavioral

Primary outcomes

  1. Change in refractive error in myopia in 6 monthly intervals for 2 years

  2. Change in axial length in 6 monthly intervals for 2 years

  3. Age effects on refractive changes over 2 years

Secondary outcomes

  1. Change in accommodative response in 6 monthly intervals for 2 years

  2. Change in accommodative facility in 6 monthly intervals for 2 years

  3. Change in peripheral refraction in 6 monthly intervals for 2 years

  4. Change in AC/A ratio in 6 monthly intervals for 2 years

Sponsors and collaborators

Lead sponsor

Anglia Ruskin University

Other

Collaborators

  • Vision CRC

Registry information

Official study title

Accommodation Training and Aberration Control in Myopia Development

Important dates

Study start
2005
First posted
Apr 25, 2006
Registry last updated
Oct 17, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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