Calcium Retention as Influenced by Dietary Components That Induce an Acid Load

The impact of protein sources such as beef as part of Western diet on calcium retention remains controversial. We propose to test the hypothesis that the positive effect of high protein intake (especially from meat protein) can offset the negative effect of protein-induced net acid load on bone metabolism and the retention of body calcium. Healthy postmenopausal women recruited from the community will consume two diets differing in meat protein and acid load for 7 weeks. Calcium retention from diets will be determined using a highly sensitive measurement of whole body retention of a calcium isotope added to the diet.

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Key information

Conditions

Healthy

Age range

40 year–75 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

United States Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, 58202, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Average body mass index
Normal blood work
Normal bone density

Exclusion criteria

Chronic disorder
Non-traumatic bone fractures

Treatment and study plan

High Meat - High Potential Renal Acid Load (PRAL) diet

Other

Menu high in meat protein

Low Protein - Low Potential Renal Acid Load (PRAL) diet

Other

Menu low in meat protein

Primary outcomes

Calcium Absorption

Time frame: 18 weeks

After 3 weeks equilibration to the diet, the 2-day menu was extrinsically labeled with Calcium-47 radiotracer and retention was monitored for 28 days by whole body scintillation counting. Percent Calcium-47 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic plot of percent Calcium-47 retained vs time.

Sponsors and collaborators

Lead sponsor

USDA Grand Forks Human Nutrition Research Center

Fed

Registry information

Official study title

Calcium Retention in Postmenopausal Women as Influenced by Beef and Other Dietary Components That Induce an Acid Load

Important dates

Study start: 2008
Primary completion: 2008
Study completion: 2008
First posted: Feb 21, 2008
Registry last updated: Jul 2, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed