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OpenTrials
Completed

NCT Number: NCT06309069

Calcified Cerebral Embolism: a Descriptive Study in a Large Single Center Cohort

Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series. The aim of this study was to describe clinical and radiological characteristics of CCE in a large number of patients, and to compare patients with different radiological CCE characteristics.

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Key information

Conditions

Calcified Cerebral Embolism Brain Diseases Brain Infarction Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebral Infarction Cerebrovascular Disorders Infarction Ischemia Necrosis Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nîmes

Nîmes, 30029, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with CEE treated with intravenous thrombolysis (IVT) between 2015 and 2020 managed at the CHU de Nîmes or Patients with TIA/stroke with ECC identified on CT between 12/2019 and 04/2023 managed at CHU de Nîmes

Exclusion criteria

  • Patient's refusal to use his/her data

Treatment and study plan

None, purely observational study

Other

None, purely observational study

Primary outcomes

  1. Calcified aortic brachiocephalic

    Time frame: baseline

    looking for calcified aortic brachiocephalic (presence or absence)

  2. cardiovascular risk

    Time frame: baseline

    Study of cardiovascular risk factors (presence or absence)

  3. history of stroke

    Time frame: baseline

    Presence of a history of stroke (y/n)

  4. Population

    Time frame: baseline

    demographic characteristics age (years)

  5. Population

    Time frame: baseline

    demographic characteristics sexe (M/F)

  6. history of surgical/endovascular cardiovascular intervention

    Time frame: baseline

    surgical/endovascular cardiovascular intervention (y/n)

  7. NIHSS

    Time frame: baseline

    NIHSS score (Score between 1 and 4: minor stroke, Score between 5 and 15: moderate, stroke, Score between 15 and 20: severe stroke) Score > 20: severe stroke

  8. calcified aortic arch

    Time frame: baseline

    looking for calcified aortic arch (presence/absence)

  9. calcified carotid

    Time frame: baseline

    looking for calcified carotid (presence/absence)

  10. atherosclerotic plaques

    Time frame: baseline

    looking for atherosclerotic plaques (presence/absence)

  11. calcified aortic valves

    Time frame: baseline

    looking for calcified aortic valves (presence/absence)

  12. calcified mitral valves

    Time frame: baseline

    looking for calcified mitral valves (presence/absence)

  13. CCE diameter

    Time frame: baseline

    CCE diameter measurement (mm)

  14. density

    Time frame: baseline

    CCE density (uh)

  15. involved cerebral artery

    Time frame: baseline

    description of involved cerebral artery

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Acronym: CCE Cohorte

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Mar 13, 2024
Registry last updated
Jan 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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