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Completed

NCT Number: NCT07001176

Caffeine, Resistance Exercise and Muscle/Cerebral Oxygenation

Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance. However, the mechanism responsible for this ergogenic effect remains to be elucidated.

Objectives: This study aims to evaluate the acute effects of caffeine intake on muscle and cerebral oxygen during muscular strength, power, muscle endurance performance. and muscle electrical activity in young adults.

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Key information

Conditions

Caffeine and Resistance Exercise

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, Spain

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 35 years.
  • Body Mass Index (BMI) < 25 kg/m².
  • Resistance-trained individuals (more than 2 years of structured training).
  • Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
  • Participants must be able to perform the tests described in the following section.

Exclusion criteria

  • History of neuromuscular diseases, heart disease, or conditions that may affect liver or muscle metabolism.
  • Use of drugs, stimulants, or sports supplements that could interfere with the dietary supplement used in the study.
  • Sedentary habits (less than 150 minutes/week of moderate exercise).
  • Having undergone prolonged periods of physical inactivity in the 6 months prior to the study.
  • Engaging in strenuous exercise within 48 hours prior to the tests.
  • Failure to replicate the same food intake on both experimental days.
  • Consumption of caffeine or any other stimulant after 6 pm on the day before the tests, to avoid headaches, discomfort, or lethargy in regular caffeine consumers.

Treatment and study plan

Caffeine

Dietary Supplement

Acute caffeine intake (3 mg/kg)

Placebo

Dietary Supplement

Acute placebo intake (3 mg/kg)

Primary outcomes

  1. Muscle Oxygenation

    Time frame: Through study completion, an average of 2 weeks

    Measuring oxygen in the muscle before and after exercise.

  2. Cerebral oxygenation

    Time frame: Through study completion, an average of 2 weeks

    Measuring cerebral oxygenation before and after exercise.

  3. Number of repetitions performed in 1 set at 65%1RM until task failure

    Time frame: Through study completion, an average of 2 weeks

  4. Bar velocity deplacement performed in 1 set at 65%1RM until task failure

    Time frame: Through study completion, an average of 2 weeks

    In bench press and back squat exercises

  5. Power output generated in 1 set at 65%1RM until task failure

    Time frame: Through study completion, an average of 2 weeks

    In bench press and back squat exercise

Sponsors and collaborators

Lead sponsor

University of Alcala

Other

Registry information

Official study title

Effect of Acute Caffeine Intake on Muscle and Cerebral Oxygenation During Muscular Strength, Power, and Endurance Performance

Acronym: CAF+RE+Oxy

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jun 3, 2025
Registry last updated
Jun 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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