Skip to main content
OpenTrials
Completed

NCT Number: NCT04320446

Caffeine Increases Maximal Fat Oxidation During Exercise in Endurance-trained Men: is There a Diurnal Variation

Maximal fat oxidation during exercise (MFO) and the intensity of exercise that elicits MFO (Fatmax) has been recognized as potential determinants of endurance performance.

The purpose of this study was to determine the possible interaction between the effects of diurnal variation (morning vs. afternoon) and caffeine ingestion on MFO, Fatmax and VO2 max in endurance-trained men. Specifically, the investigators sought to elucidate whether the stimulant actions of caffeine could reverse the decrements of MFO and Fatmax observed in the morning.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Energy Metabolism Athletic Performance

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Instituto Mixto Universitario Deporte Salud

Granada, 18016, Spain

About this study

Body weight, height, body composition (DXA), exercise test (MFO and VO2max assessment) will be measured during the 4 evaluations.

Participants were randomized into 4 exercise test conditions:

  • Exercise test in the morning with placebo intake
  • Exercise test in the evening with placebo intake
  • Exercise test in the morning with caffeine intake
  • Execrise test in the evening with caffeine intake

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Having a body mass index (BMI) ranged from 18.5 to 28 kg/m2
  • not suffering any specific disease which can be aggravated by physical exercise
  • having previous experience in endurance training (i.e. self-reporting at least 2 years of cycling or running training including more than 3 training sessions/week).
  • Participant must be capable and willing to provide consent, understand exclusion criteria, instructions and protocols.

Exclusion criteria

  • Being smoker
  • Taking medication or drugs
  • Any non-controlled medical condition which could influence results or could be worsened by the participation in the study
  • Are deemed unsuitable by the investigator for any other reason, that prevent data collection.

Treatment and study plan

Test in the morning

Behavioral

The exercise test was performed between 8 a.m and 11 a.m

Other names: MFO-morning, Fatmax-morning, and VO2max-morning

Test in the afternoon

Behavioral

The exercise test was performed between 5 p.m. and 8 p.m.a

Other names: (MFO-afternoon, Fatmax-afternoon, and VO2max-afternoon

Primary outcomes

  1. MFO

    Time frame: Through study completion, an average of 1 month

    Maximal fat oxidation during exercise

Secondary outcomes

  1. FATmax

    Time frame: Through study completion, an average of 1 month

    The intensity of exercise that elicits MFO

  2. VO2max

    Time frame: Through study completion, an average of 1 month

    Cardiorrespiratory fitness measured by maximal oxygen uptake

Sponsors and collaborators

Lead sponsor

Universidad de Granada

Other

Registry information

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Mar 25, 2020
Registry last updated
Mar 25, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.