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Completed

NCT Number: NCT03367806

Caffeine Consumption and Mortality in Diabetes

Previous studies suggested an inverse relationship between coffee consumption and mortality in the general population. Furthermore, an inverse association between coffee consumption and serum biomarkers of inflammation and insulin resistance has been described. Prospective studies showed that coffee consumption might be associated with reduction in the incidence of type 2 diabetes. Although caffeine consumption appears to be associated with a decreased risk of developing type 2 diabetes, the relationship between caffeine consumption and mortality in patients with diabetes remains uncertain. The current analysis aimed to assess the effects of caffeine consumption and caffeine source on all-cause, cardiovascular and cancer mortality among patients with diabetes.

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Key information

Conditions

Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • NHANES participants from 1999 to 2010 above 18-year old, with diagnosis of diabetes

Exclusion criteria

  • Implausible alimentary reports (defined as consumption of less than 500 kcal/day or more than 3500 kcal/day)
  • Missing information on caffeine consumption
  • Missing information on mortality

Treatment and study plan

Primary outcomes

  1. All-cause mortality

    Time frame: From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years

    All-cause mortality as assessed by NHANES linked National Death Index public-access

Secondary outcomes

  1. Cardiovascular mortality

    Time frame: From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years

    Cardiovascular mortality as assessed by NHANES linked National Death Index public-access

  2. Cancer mortality

    Time frame: From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years

    Cancer mortality as assessed by NHANES linked National Death Index public-access

Sponsors and collaborators

Lead sponsor

João Sérgio Neves

Other

Registry information

Official study title

Caffeine Consumption and Mortality in Diabetes: an Analysis of National Health and Nutrition Examination Survey (NHANES) 1999-2010

Important dates

Study start
1999
Primary completion
2011
Study completion
2011
First posted
Dec 11, 2017
Registry last updated
Dec 11, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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