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OpenTrials
Completed

NCT Number: NCT04886869

Caffeine and the Autonomic Nervous System

Caffeine consumption has been linked to dysfunction of the autonomic nervous system. In this study the investigators analyze the effects of caffeine containing drinks (including energy drinks and coffee) on ECG based parameters of the autonomic nervous system.

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Key information

Conditions

Autonomic Nervous System Imbalance

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Munich (LMU Klinikum)

Munich, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy individuals
  • > 18 years

Exclusion criteria

  • known cardiovascular disease
  • other diseases which may influence the autonomic nervous system
  • medication which may influence the autonomic nervous system
  • prior caffeine consumption (<24 hours)

Treatment and study plan

Caffeine

Dietary Supplement

oral consumption

Primary outcomes

  1. Heart rate (HR)

    Time frame: 2 hours

    ECG-based analysis of heart rate (beats per minute)

Secondary outcomes

  1. Periodic repolarization dynamics (PRD)

    Time frame: 2 hours

    ECG-based analysis of repolarization instability (deg²)

Sponsors and collaborators

Lead sponsor

LMU Klinikum

Other

Registry information

Official study title

Impact of Caffeine Consumption on Markers of the Autonomic Nervous System

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
May 14, 2021
Registry last updated
Mar 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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