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Completed

NCT Number: NCT03482726

Cadence Modulation to Improve Well-Being, Kinematics and Aerobic Performance in Cyclists

This study will utilize a combination of cardiovascular analysis, 3D motion capture, and a software package, Metrifit, to monitor measures of well-being to comprehensively evaluate both the musculoskeletal and physiological responses following a HIIT training intervention at EOC as a means of improving performance and potentially reducing injury risk factors. This holistic approach of physiological and biomechanical factors is unprecedented. This is the first interventional study to determine the effect of high intensity training at EOC on cardiovascular performance, kinematics and well-being which may minimize risk of injury factors.

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Key information

Conditions

Age range

18 year–89 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Wisconsin

Madison, Wisconsin, 53705, United States

About this study

In the first session, each individual will be asked to fill out a questionnaire to regarding cycling experience, prior bike fits (with data sheets when available), and injury history. Maximal aerobic capacity (VO2max) will be determined. During the test, subjects will be asked rate exertion. Before testing, the system will be calibrated with known oxygen and carbon dioxide concentrations. During the test, subjects will be asked to breathe normally through a low dead space bidirectional turbine. Inspired and expired gases will be analyzed for concentrations of O2 and CO2, to determine alveolar gas exchange. Total ventilation (VE), respiratory rate, oxygen consumption (VO2), carbon dioxide (VCO2) will be measured, and respiratory exchange ratio (RER; VCO2/VO2) will be calculated continuously during the test and expressed as a 30-second rolling average.

Participants will return 48 hours later, at which time EOC will be determined after a moderate intensity prolonged cycling exercise (PCE) at seven different cadences. Cadences from 50rpm to 110rpm will be randomly generated and introduced every 3 minutes, followed by a 3 minute cool down at FCC at 40% PP (Figure Subjects will then be pair matched by gender and randomized into control (FCC) or EOC modulation groups.

48 hours following EOC testing, subject will return for a second progressive maximal cycling test performed at FCC or EOC based on group assignment.

Subjects will then participate in a 6 week high intensity training (HIIT) indoor cycling program at their prescribed cadence (FCC or EOC), using cadence meters. Training will consist of three non-consecutive days each week for 60 min, and alternate between two HIIT workouts. Resistance will be increased to meet the HIIT requirement, while cadence will remain at FCC or EOC. Subjects will be asked to warm-up at a light (3/10) workload for 10 minutes, followed by HIIT consisting of 4 minutes at an intensity of 8/10 on the modified Borg, and 90 seconds recovery (2/10). This will be repeated 8 times, followed by 10 minutes of cool down. The alternating HIIT workout will include a 10 minute warm up, followed by 12 intervals lasting 2 minutes at an RPE of 9/10 and 3 minutes of recovery. The session will conclude with a 10 minute cool down.

Within one week of completing their training program, subjects will return for their fourth and final study visit, at which time a VO2max test and kinematic data collection will be repeated at FCC or EOC.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • An experienced cyclist will be defined as one with at least 5 years of cycling experience and 5000 miles of training on a road bike with a clipless pedal system.
  • Able to tolerate strenuous, maximal exercise and comply with a 6 week training protocol
  • Have access to an indoor trainer or spin bike with a cadence sensor in order to train 3 times per week for 60 minutes

Exclusion criteria

  • Taking medication which could impact cardiovascular function or performance (stimulants, beta-blockers, e.g.)
  • Significant cardiac or pulmonary disease (congenital cardiac disease, uncontrolled hypertension, uncontrolled asthma, e.g.)
  • Musculoskeletal injuries that preclude a maximal cycling effort and participation in training program

Treatment and study plan

Cycling Cadence Modulation

Behavioral

6-week high intensity training (HIIT) indoor cycling program, described later, at their prescribed cadence (FCC or EOC), using cadence meters.

Primary outcomes

  1. Time to exhaustion T(max)

    Time frame: Baseline

    time to reach exhaustion

  2. Ventilatory threshold (VT)

    Time frame: Baseline

  3. Maximal cardiac output

    Time frame: Baseline

  4. Maximal stroke volume

    Time frame: Baseline

  5. decreased trunk lean

    Time frame: Baseline

    decrease in degree of lean in truck

  6. decreased ankle dorsiflexion

    Time frame: Baseline

    decrease in amount of ankle dorsiflexion

  7. decreased knee splay

    Time frame: Baseline

    decreased degree of knee splay

Secondary outcomes

  1. Improved VO2 max

    Time frame: 6 weeks

    Increased maximum O2 volume

  2. Increased O2 consumption at VT

    Time frame: 6 weeks

    Improved oxygen consumption at ventilatory threshold

  3. Time to VT

    Time frame: 6 weeks

    Improved time to reach ventilatory threshold

  4. Time to T(max)

    Time frame: 6 weeks

    Improved time to reach exhaustion

  5. decreased trunk lean

    Time frame: 6 weeks

    decrease in degree of lean in truck

  6. decreased ankle dorsiflexion

    Time frame: 6 weeks

    decrease in amount of ankle dorsiflexion

  7. decreased knee splay

    Time frame: 6 weeks

    decreased degree of knee splay

  8. change in overall soreness and fatigue

    Time frame: 6 weeks

    decrease in reported soreness and fatigue as measured and reported via Metrifit software

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Registry information

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Mar 29, 2018
Registry last updated
Dec 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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