CABG Based on CT-FFR Versus Conventional Coronary Angiography

The CABG-COREA trial is designed as a randomized, controlled trial to recruit 96 patients who undergo coronary artery bypass grafting. Patients were randomized by use of a randomization table. Coronary arteries are revascularized based on conventional coronary angiography (quantitative coronary angiography) or cardiac computed tomography-derived fractional flow reserve according to the randomization result.

The primary end point is to evaluate early and 1-year postoperative graft patency. The secondary end points are overall survival, freedom from cardiac death and freedom from MACCE(major adverse cardiac or cerebrovascular events).

Inclusion criteria

• age equal or more than 40
• age equal or less than 80
• patients who undergo coronary artery bypass grafting due to multi-vessel coronary artery disease
• patients who agree to the enrollment

Exclusion criteria

• Patients with heart failure (left ventricular ejection fraction < 25%)
• patients who have intractable ventricular arrhythmia
• patients who has been treated for cancer
• patients who has infectious disease
• patients who are planned to undergo combined cardiac surgery
• patients who has medical co-morbidity with expected survival less than 1 year
• patients with a history of previous cardiac surgery
• Patients with chronic renal failure requiring dialysis
• patients who undergo emergency operation