ButCoIns - Metabolic Effects of Resistent Starch and Arabinoxylans in Subjects With Metabolic Syndrome

Background Life style related disease is an increasing problem all over the world. The Metabolic Syndrome (MetS) is a condition characterized by abdominal obesity, dyslipidemia, hypertension and impaired glucose tolerance. Subjects with MetS have high risk of developing Type 2 Diabetes and CVD.

Resistant Starch (RS) and Arabinoxylans (AX) are dietary fibers that have been shown to have positive effects on the components of MetS. The combination of RS and AX has not been tested before .

Hypotheses Increase of RS and AX in the dietary composition has a positive effects on components of MetS i.e. decreases postprandial lipaemia, improves glucose tolerance, insulin resistance, blood pressure and markers of inflammation.

Design:

A nonblinded randomized cross over study Two dietary interventions of 4 weeks duration each. A healthy carbohydrate Diet with a high content of RS and AX is compared to a Western Style diet with a low content of RS and AX. Between the two interventions, there is a wash out period of 4 weeks.

The primary outcome is postprandial lipaemia estimated by a high fat meal test of 6 hours duration. The test is performed before and after each intervention.

Secondary outcomes are:

• Glucose tolerance and insulin resistance estimated by OGTT
• 24 hours blood pressure
• MRI estimation of liver fat content
• Postprandial changes in genes of adipose tissue

Inclusion criteria

At least 3 out of the 5 following criterions

• Central obesity (Female >80 cm, Male >94)
• HDL cholesterol (female < 1,03 mmol/l, male < 1,29 mmol/l)
• Blood Pressure (> 130/85)
• Fasting Blood Glucose > 5,6 mmol/L

Exclusion criteria

• Diabetes
• Gastrointestinal disease
• Anticoagulation treatment
• Serious liver, heart or kidney disease
• Anaemia
• Corticosteroid treatment
• Waist circumference above 130 cm
• Alcohol or drug addiction
• Pregnancy og lactation