Sixth Medical Center of Chinese PLA General Hospital
Beijing, China
NCT Number: NCT07512037
Traditional AF classification (e.g., paroxysmal, persistent, permanent) relies largely on patient-reported symptoms and intermittent electrocardiographic monitoring, which cannot continuously or objectively reflect disease progression, nor effectively inform optimal intervention timing. Although "AF burden" (i.e., duration of AF episodes) has emerged as a potential marker, its association with clinical outcomes remains inconsistent due to limitations in monitoring methods and its one-dimensional nature. Based on our previous work, investigators developed a five-dimensional AF progression model using photoplethysmography (PPG) signals collected from wearable devices. This model quantifies AF progression across five domains: episode frequency, duration, temporal aggregation, circadian rhythm, and tachycardia burden, enabling continuous and multidimensional assessment. Prior validation has demonstrated high agreement with 24-hour Holter monitoring and effective identification of high-risk patients.
The BEAT-AF trial is designed to evaluate the clinical utility of this model in a real-world setting. Specifically, investigators will investigate whether early intervention (e.g., optimization of medical therapy or consideration of catheter ablation) in patients with elevated five-dimensional AF burden (≥4.59%) can reduce symptoms, rhythm/rate-related abnormalities, and AF-related adverse events (such as stroke and heart failure). This study is expected to provide new evidence for dynamic monitoring of AF progression, optimal timing of intervention, and personalized management strategies, ultimately improving patient outcomes.
Trial opening soon.
Get Notified18 year and older
All sexes
Interventional
Not applicable
Beijing, China
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Continuous PPG-based AF monitoring; Threshold-triggered intervention; Stepwise rhythm control strategy; Antiarrhythmic drug optimization; Catheter ablation evaluation; Anticoagulation management; Comorbidity management; Digital follow-up and education;
Time frame: 12 months
The occurrence of the AF-related composite adverse event endpoint, which consists of any of the following events: progression of atrial fibrillation, heart failure, stroke, systemic embolism, and cardiovascular-related hospitalization.
Time frame: 24 months
Atrial fibrillation symptoms (EHRA symptom score)
Time frame: 24 months
The overall load of 5D-AF at the assessment time point < 4.59%
Time frame: 24 months
Atrial fibrillation progression, heart failure, stroke, systemic embolism, transient ischemic attack, venous thromboembolism, cardiovascular-related hospitalization, all-cause hospitalization, cardiovascular-related mortality, all-cause mortality, bleeding events, and the rate of catheter ablation treatment for atrial
Time frame: 24 months
quality of life score(EQ-5D-5L)
Time frame: 24 months
cognitive function changes (MoCA score)
Contact information is provided by the study sponsor or research team.
JIN ZHI-GENG, Doctor
CONTACT
86+15801402223
YU-TAO GUO, Doctor, Study Chair
CONTACT
86+13810021492
Navy General Hospital, Beijing
Other
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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