Skip to main content
OpenTrials
Completed

NCT Number: NCT03920319

Bupropion and Cigarette-Related Cues in Smokers

Randomized, double-blind, before-after controlled trial to assess changes in regional brain activation in response to cigarette-related cues from before to after treatment with bupropion (vs placebo).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Smoking Behavior Smoking, Tobacco Tobacco Smoking Tobacco Use

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Treatment-seeking cigarette smoker
  • Meet DSM-IV criteria for nicotine dependence
  • Negative result on urine test for drug use during screening

Exclusion criteria

  • History of any Axis I psychiatric diagnosis other than nicotine dependence
  • Medical conditions that might affect brain function
  • Current use of medications that could alter brain function
  • Pregnancy
  • Current illicit drug use other than occasional use of marijuana

Treatment and study plan

bupropion

Drug

Bupropion 150 mg sustained release

Other names: bupropion HCl, Wellbutrin

Placebo

Other

Primary outcomes

  1. Craving ratings

    Time frame: 8 weeks

    Participants were instructed to respond from 1 (definitely not) to 5 (definitely) on the question, "I crave a cigarette right now", after viewing video cues.

Secondary outcomes

  1. Exhaled carbon monoxide (CO)

    Time frame: 8 weeks

    Participants were asked to hold their breath for as long as possible, ideally 15 seconds, then to breathe out slowly into the mouthpiece of a CO monitor, aiming to empty the lungs completely.

  2. Cigarettes per day

    Time frame: 8 weeks

    Self-reported number of cigarettes smoked daily during the past 7 days [??]

  3. Fagerström Test for Nicotine Dependence (FTND)

    Time frame: 8 weeks

    The FTND contains six items that evaluate the quantity of cigarette consumption, the compulsion to use, and dependence. The yes/no items are scored from 0 to 1 and multiple-choice items are scored from 0 to 3. The items are summed to yield a total score of 0-10. The higher the total Fagerström score, the more intense is the patient's physical dependence on nicotine.

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Registry information

Official study title

Effect of Bupropion Treatment on Brain Activation Induced by Cigarette-Related Cues in Smokers

Important dates

Study start
2004
Primary completion
2005
Study completion
2005
First posted
Apr 18, 2019
Registry last updated
Apr 18, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.