Buprenorphine in the Emergency Department

This is a pilot randomized control trial randomizing patients presenting in opioid withdrawal to the emergency department to receive either one of clonidine (usual standard of care) or buprenorphine for their opioid withdrawal. Primary treatment outcome is attendance at a rapid access addiction medicine clinic within a few days of emergency room presentation. Secondary treatment outcome is treatment status with respect to opioid agonist treatment at one month post emergency room visit.

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Key information

Conditions

Opioid Withdrawal Chemically-Induced Disorders Disease Attributes Emergencies Mental Disorders Narcotic-Related Disorders Opioid-Related Disorders Opioid-use Disorder Pathologic Processes Pathological Conditions, Signs and Symptoms Substance-Related Disorders

Age range

16 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Presenting to the ED in opioid withdrawal or soon to be in withdrawal
Minimum age 16
English speaking
Active phone number
Ontario Health Insurance Program card

Exclusion criteria

Pregnant
Currently enrolled in a methadone or buprenorphine maintenance
Benzodiazepine addiction (or taking >50mg of valium equivalent/day)
Acute hepatitis or liver failure

Treatment and study plan

buprenorphine

Drug

The participant receives buprenorphine

Clonidine

Drug

The participant receives clonidine

Primary outcomes

Number of participants attending the rapid access clinic

Time frame: 2-5 days

The number of participants who attend a rapid access clinic assessment after initial enrollment

Secondary outcomes

Number of participants who are on opioid agonist treatment

Time frame: 30 days

The number of participants who are maintained on some form of opioid agonist treatment at the one-month mark

Sponsors and collaborators

Lead sponsor

St. Joseph's Health Centre Toronto

Other

Registry information

Official study title

Buprenorphine in the Emergency Department: Buprenorphine Versus Clonidine for Opioid Withdrawal

Acronym: BED

Important dates

Study start: 2013
Primary completion: 2016
Study completion: 2016
First posted: Jun 2, 2017
Registry last updated: Jun 2, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed