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Completed

NCT Number: NCT07469826

Bupivacaine Alone vs Bupivacaine With Tramadol in Local Anesthesia Procedures

This study looked at two different medicines used during local anesthesia to control pain after surgery. Investigators compared bupivacaine alone with bupivacaine mixed with tramadol. Both medicines are commonly used to numb the surgical area and reduce pain.

The investigators included 100 adult patients who had minor surgeries under local anesthesia. Half received only bupivacaine, and the other half received bupivacaine combined with tramadol. After surgery, patients were asked to rate their pain at 4, 8, and 24 hours.

The results showed that patients who received bupivacaine with tramadol felt less pain, especially at 24 hours after surgery, compared to those who received bupivacaine alone.

In simple words:

Adding tramadol to bupivacaine helps reduce pain better than bupivacaine alone.

This method may help patients recover faster, feel more comfortable, and need fewer pain medicines after surgery.

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Key information

Conditions

Post Operative Pain, Acute Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Jinnah postgraduate medical university

Karachi, Sindh, 75510, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients undergoing elective procedure under local anesthesia
  • Either gender.
  • Age 18-60 years.

Exclusion criteria

  • Procedures Under general anesthesia.
  • Diabetic patients, assessed by history and clinically and HbA1c >6.5%
  • Patients with metastatic disease, assessed by history, clinically and by imaging.
  • Patients who are I/V opioid abusers will be excluded.

Treatment and study plan

Tramadol

Drug

A single dose of 1 mg/kg tramadol at the surgical site

Bupivacaine

Drug

Single dose 0.5 ml/kg of 0.25% Bupivacaine at surgical site

Primary outcomes

  1. Mean postoperative pain score

    Time frame: Patients were monitored for 24 hours immediately following the completion of the surgical procedure

    Mean postoperative pain score using the visual analog scale at 4,8 and 24 hours postoperatively. Visual Analog Scale (VAS) is a 10-cm horizontal line ranging from 0 (no pain) to 10 (worst imaginable pain). Patients will mark the point representing their pain intensity. Scores will be recorded at predetermined postoperative intervals.

Sponsors and collaborators

Lead sponsor

Jinnah Postgraduate Medical Centre

Other Gov

Collaborators

  • Jinnah Sindh Medical University

Registry information

Official study title

Efficacy of Bupivacaine Alone and Bupivacaine With Tramadol in Local Anesthesia Procedures

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Mar 13, 2026
Registry last updated
Mar 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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