Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06870578

Building Research for Intervention Development in Gliosis and Eating Habits

The goal of this study is to 1) use magnetic resonance imaging (MRI) to evaluate the effect of nutritious foods on inflammation in the human hypothalamus of children and 2) assess the feasibility and acceptability of nutritious food feeding intervention strategies in children with overweight or obesity.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Gliosis Body Weight Child Obesity Eating Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathologic Processes Pathological Conditions, Signs and Symptoms Pediatric Obesity Signs and Symptoms

Age range

9 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Washington

Seattle, Washington, 98109, United States

Location status: Recruiting

Location contact

BRIDGE Study

CONTACT

[email protected]

206-616-6360

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Study1: Adult caregiver and Child age 9-11y. Willing to come to in-person focus group
  • Study 2: Age 9-11y, BMI ≥85th and ≤95th percentile for age and sex
  • Study 3:Adult caregiver with child who qualify for free or reduced-cost lunch in WA State. Child age 9-11y and with overweight.

Exclusion criteria

(study 1 child participants and study 3 criteria for children of adult participants):

  • Significant health conditions including type 2 diabetes
  • History of major weight loss or eating disorder
  • Current use of medications known to alter appetite or body weight (e.g., stimulants for ADHD)
  • Documented cognitive disorder
  • Severe food allergies, vegetarian, or vegan (Study 1 only)
  • Unable to make the session date

Exclusion criteria

(study 2, child participants):

  • Significant health conditions including type 2 diabetes
  • History of major weight loss or eating disorder
  • Current use of medications known to alter appetite or body weight (e.g., stimulants for ADHD)
  • Documented cognitive disorder
  • MRI contraindication (e.g., braces, claustrophobia)
  • Weight >330 pounds (MRI limit)
  • Severe food allergies, vegetarian, or vegan
  • Currently in formal weight loss program

Treatment and study plan

Diet modification

Other

In Study 2 only, children will be provided all meals for a 7-day period. Meals will consist of nutritious foods, calories provided will exceed the child's estimated daily caloric need, and children will be asked to consume meals ad libitum.

Primary outcomes

  1. T2 relaxation time by brain MRI

    Time frame: 7 days of diet intervention

Study contacts

Contact information is provided by the study sponsor or research team.

BRIDGE Study

CONTACT

[email protected]

206 616-6360

Sponsors and collaborators

Lead sponsor

University of Washington

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Official study title

Fostering Patient-oriented Research in Cardiometabolic Disease Pathogenesis and Prevention

Acronym: BRIDGE

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Mar 11, 2025
Registry last updated
Jun 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.