Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient

The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia. The team plans to build the first of its kind comprehensive database of demographic and risk factor questionnaire responses, biobanked blood specimens, intraoperative electroencephalography (EEG), and inclusive cognitive testing throughout patient interaction starting at the preop appointment until a year later. This will be used to create a predictive model of periooperative neurocognitive disorders.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Cognitive Decline Anesthesia; Adverse Effect Anesthesia; Reaction Cognition Disorders Cognitive Change Cognitive Dysfunction Cognitive Impairment Confusion Delirium Emergence Delirium Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Delirium Signs and Symptoms

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford Medical Center

Stanford, California, 94305, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

At least 65 years old (inclusive)
Non cardiac general elective surgery
General anesthesia is expected for 2+ hours

Exclusion criteria

Alzheimer's
Dementia
Parkinson's
History of neurodegenerative diseases
Medication for depression (ie. Benzodiazepines)
Alcoholism
Discretion of PI

Treatment and study plan

Neurocognition Interventions

Combination Product

EEG, Neurocognitive Battery Testing, and Immune Profiles

Primary outcomes

Postoperative Neurocognitive Disorders

Time frame: 3 years

Neurocognitive Assessment Battery

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2030
Study completion: 2030
First posted: Feb 15, 2019
Registry last updated: Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting