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NCT Number: NCT06630819

Buccal Infiltration of Different Volumes of Articaine for Extraction.

This study compares the effectiveness of two different volumes of buccal infiltration of Articaine for the extraction of mandibular posterior teeth. One group receives buccal infiltration of 1.8 ml of 4% Articaine and the other group receives buccal infiltration of 3.6 ml of 4% Articaine.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Qassim University, Buraidah, Al Qassim, Saudi Arabia

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About this study

The most widely and commonly used injection method for the extraction of mandibular posterior teeth is the inferior alveolar nerve block (IANB) technique. However, various complications like pain during injection, transient facial nerve paralysis, trismus, hematoma, and paresthesia are associated with the inferior alveolar nerve block technique.

Local infiltration technique has been proven as a safer and less painful anesthetic injection technique compared to IANB. Unfortunately, the dense nature of cortical bone in the mandibular posterior region hinders sufficient diffusion of anesthetic solution during infiltration. Thus, to achieve an adequate anesthesia for a painless dental extraction of mandibular posterior teeth by infiltration technique, a strong and effective local anesthetic agent having a deeper penetrating property should be used.

Articaine is one of the most widely used local anesthetic agents. It is more potent and has shown more success rate than Lidocaine and Mepivacaine in providing anesthesia in mandibular and maxillary posterior teeth by buccal infiltration diffusibility.

This study compares the effectiveness of two different volumes of buccal infiltration of Articaine for the extraction of mandibular posterior teeth.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All healthy patients (ASA I) or patients with mild systemic disease with no functional limitations (ASA II)
  • Patients aged ≥ 18 years of age.
  • Patients requiring extraction of mandibular posterior teeth including grossly decayed tooth, grade I mobile tooth, root stumps and indicated for therapeutic reasons.
  • Patients not allergic to the drugs or anesthetic agents used in the surgery.

Exclusion criteria

  • Acute infection at the extraction site.
  • Patients indicated for surgical extraction of teeth.
  • Patients already taking medications affecting pain assessment.
  • Pregnant patients.

Treatment and study plan

1.8 ml of 4% Articaine

Other

Buccal infiltration of 1.8 ml of 4% Articaine

3.6 ml of 4% Articaine

Other

Buccal infiltration of 3.6 ml of 4% Articaine.

Primary outcomes

  1. Intensity of pain

    Time frame: From reflection of mucoperiosteum till delivery of tooth out of socket.

    VAS scale is a validated scale measuring pain with possible score range from 0 (no pain) to 100 (severe pain).

  2. Time of onset of anesthesia

    Time frame: upto 10 minutes

    It will be assessed by probing buccal and lingual soft tissue using a dental explorer every 2 minutes after infiltration using a standard digital stop clock.

  3. Presence or absence of pain

    Time frame: From reflection of mucoperiosteum till delivery of tooth out of socket.

    A 100 mm Numerical rating scale assessing intraoperative pain. Possible score ranges from 0 (no pain) to 100 (worst possible pain).

Study contacts

Contact information is provided by the study sponsor or research team.

Abdul K Azad

CONTACT

[email protected]

00966594914343

Muhammad Atif S Agwan

CONTACT

[email protected]

966541651713

Sponsors and collaborators

Lead sponsor

Qassim University

Other

Registry information

Official study title

Comparing the Effectiveness of Buccal Infiltration of Different Volumes of Articaine for Extraction of Mandibular Posterior Teeth- A Randomized Clinical Trial.

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Oct 8, 2024
Registry last updated
May 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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