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OpenTrials
Active, Not Recruiting

NCT Number: NCT07098546

'Bubble Time' in Pulmonary Embolism

The study will be multi-centre and prospectively planned. All patients who undergo contrast-enhanced computed tomography in the emergency department with a preliminary diagnosis of pulmonary embolism and who do not meet the exclusion criteria will be included in the study. Informed consent will be obtained from all patients prior to the study. Patients included in the study will undergo bedside ultrasound to assess bubble time, right ventricle-left ventricle ratio, presence of a septal defect, and tricuspid insufficiency, and the diagnostic value of these findings will be evaluated. The bedside ultrasound will be part of the emergency department critical care examination, will not incur any costs for the institution, and will be performed and evaluated by an emergency medicine specialist and assistant.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Recep Tayyip Erdoğan Üniversitesi Rize Eğitim ve Araştırma Hastanesi

Rize, Merkez, 53020, Turkey (Türkiye)

About this study

The study will be multi-centre and prospectively planned. All patients who undergo contrast-enhanced computed tomography in the emergency department with a preliminary diagnosis of pulmonary embolism and who do not meet the exclusion criteria will be included in the study. Informed consent will be obtained from all patients prior to the study. Patients included in the study will undergo bedside ultrasound to assess bubble time, right ventricle-left ventricle ratio, presence of a septal defect, and tricuspid insufficiency, and the diagnostic value of these findings will be evaluated. The bedside ultrasound will be part of the emergency department critical care examination, will not incur any costs for the institution, and will be performed and evaluated by an emergency medicine specialist and assistant.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients presenting to the emergency department with any symptoms, undergoing pulmonary CT angiography due to suspected pulmonary embolism or evaluated as having a strong likelihood of embolism when CT cannot be performed will be included in the study.

Exclusion criteria

  • Patients under the age of 18
  • Patients with a severe history of tricuspid insufficiency
  • Patients with a severe of pulmonary hypertension
  • Patients with a severe of right heart failure
  • Patients without an echocardiographic report approved by cardiology within 48 hours after emergency admission
  • Patients in whom ultrasonographic measurements cannot be performed
  • Patients who refuse diagnosis and treatment voluntarily

Treatment and study plan

Primary outcomes

  1. Bubble time

    Time frame: through study completion, an average of six months

    The diagnostic value of bubble time

  2. bubble time in pulmonary embolism

    Time frame: through study completion, an average of six months

    The diagnostic value of bubble time in pulmonary embolism

Sponsors and collaborators

Lead sponsor

Recep Tayyip Erdogan University Training and Research Hospital

Other

Collaborators

  • Akdeniz University Hospital
  • Gazi University
  • Marmara University Pendik Training and Research Hospital

Registry information

Official study title

Diagnostic Value of Right Ventricular 'Bubble Time' in Pulmonary Embolism

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 1, 2025
Registry last updated
Aug 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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