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Completed

NCT Number: NCT02984514

Brown Adipose Tissue in Type 1 Diabetes

Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels.

In this study 12 patients with long-standing type 1 diabetes (>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.

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Key information

Conditions

Type1diabetes

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Uppsala University Hospital

Uppsala, 751 23, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (18 years of age or more)
  • Type 1 diabetes diagnose for more than 10 years

Exclusion criteria

  • Ongoing pregnancy
  • Ongoing breast-feeding
  • BMI<19
  • BMI >30
  • P-creatinine <110 µmol/l

Treatment and study plan

Positron emission tomography with tracer 18F-deoxy glucose

Radiation

Assessment of activity of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose

Primary outcomes

  1. Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements

    Time frame: Assessment performed after more than 10 years of diagnosed type 1 diabetes

Secondary outcomes

  1. Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements.

    Time frame: Assessment performed after more than 10 years of diagnosed type 1 diabetes

Sponsors and collaborators

Lead sponsor

Per-Ola Carlsson

Other

Registry information

Official study title

Studies of Activity of Brown Adipose Tissue With Positron Emission Tomography Using the Tracer 18F-deoxy Glucose in Patients With Type 1 Diabetes

Important dates

Study start
2015
Primary completion
2018
Study completion
2018
First posted
Dec 7, 2016
Registry last updated
Oct 11, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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