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Completed

NCT Number: NCT00666510

Bronchospasm Associated With High Nitric Oxide

Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

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Key information

Conditions

Asthma Airway Hyperresponsiveness Bronchial Diseases Bronchial Spasm Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

16 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital das Clínicas da FMUSP

São Paulo, 05430 010, Brazil

About this study

Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with no systemic disease and registered bronchospasm during anesthesia induction

Exclusion criteria

  • hypertension, COPD, diabetes, pregnancy

Treatment and study plan

Primary outcomes

  1. Exhaled nitric oxide in parts per billion

    Time frame: one to six months after surgery

Secondary outcomes

  1. Eosinophils concentration within sputum sample, pulmonary function tests

    Time frame: one to six months after surgery

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Higher Exhaled Nitric Oxide (NO) is Associated With Intraoperative Bronchospasm

Important dates

Study start
1999
Study completion
2004
First posted
Apr 25, 2008
Registry last updated
Apr 25, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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