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Completed

NCT Number: NCT01770015

Bronchial Colonization With Fungi and Late Respiratory Acquired Pneumonia

Ventilator acquired pneumonia (VAP) are severe nosocomial infections. On the other side, bronchial fungi colonization is commonly observed in ICU; therefore, the investigators propose to study the role of bronchial fungi colonization on the occurrence of VAP taking into account the immune status of the patient and the antibiotic and antifungal treatments he has received.

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Key information

Conditions

Ventilator Acquired Pneumonia Cross Infection Disease Attributes Healthcare-Associated Pneumonia Iatrogenic Disease Infections Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Ventilator-Associated Respiratory Tract Diseases Respiratory Tract Infections

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital University Clermont Ferrand Gabriel Montpied, Clermont-Ferrand, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient ventilated for at least 5 days

Exclusion criteria

  • invasive infection Candida sp defined by : candidemia, isolation of Candida from a normally sterile site, candida pneumoniae.

Treatment and study plan

biological sampling

Procedure

cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization

sampling blood

Procedure

HLA DR antigen, cytokines (IL 6 and 10), B-glucan

Endotracheal Aspiration

Procedure

fungi and bacteria endotracheal aspiration

Primary outcomes

  1. Onset of a late ventilator acquired pneumonia (VAP)

    Time frame: Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks

Secondary outcomes

  1. Onset of a pseudomonas aeruginosa associated VAP

    Time frame: Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks

  2. Onset of late ventilator associated pneumonia associated to staphylococcus aureus

    Time frame: Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Official study title

Study of the Impact of Bronchial Colonization With Fungi in the Occurrence of Late Ventilator Acquired Pneumonia

Acronym: CBF et PAVMt

Important dates

Study start
2011
Primary completion
2016
Study completion
2016
First posted
Jan 17, 2013
Registry last updated
Nov 4, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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