BRING-UP 3 Heart Failure

Observational, prospective, multicenter study conducted in a large, representative sample of Italian cardiology centers.

Phases 1:

• First educational intervention to discuss the recommendations of guidelines and treatment patterns in specific phenotypes of patients.
• Data collection for 3 months or up to 30 consecutive patients with chronic HF or acute HF (both de novo and worsening).
• Evaluation of the primary and secondary end-points of the study at 6 months after enrollment. Modifications of treatments will be monitored during the 6 months follow-up.
• Second educational intervention to share the results of the first enrollment period of the study focusing the attention on existing gaps between guidelines recommendations and clinical practice.
• New data collection for other 3 months or up to 30 consecutive patients with chronic HF or acute HF (both de novo and worsening).
• Additional evaluation of the primary and secondary end-points of the study at 6 months after enrollment. Modifications of treatments will be monitored during the 6 months follow-up.
• 12-month follow-up for all patients included in both enrolment phases of the study.

Inclusion criteria

• Age ≥18 years old.
• Males and females at birth.
• Any ejection fraction level (level of ejection fraction measured in the 6 months preceding enrollment).
• Ambulatory chronic HF or Hospitalized de-novo or worsening HF.
• Signed informed consent

Diagnosis will be made by the local attending physician following the ESC guidelines recommendations.

Exclusion criteria

• Active neoplasia or very severe disease compromising short-medium term life expectancy.
• Participation in interventional studies.
• Patients already enrolled into the study from another participating center or in the previous enrolling phase.