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NCT Number: NCT07232823

Brief Culturally Adapted CBT for OCD

The purpose aims to assess the efficacy of Brief Culturally Adapted Cognitive Behaviour Therapy (Ca-CBT) for the treatment of Obsessive Compulsive Disorder (OCD).

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Professional Association of Cognitive Therapy

Lahore, Punjab Province, 54000, Pakistan

Location status: Recruiting

Location contact

Farooq Naeem

PRINCIPAL_INVESTIGATOR

Muhammad Aslam, MSCP

CONTACT

[email protected]

+92 301 7170139

About this study

The presence of obsessions and compulsions characterises obsessive-compulsive disorder (OCD). Obsessions are intrusive, unwanted thoughts, images, or impulses that are distressing and difficult to control. These obsessive thoughts cause significant emotional discomfort. Conversely, compulsions are repetitive behaviours or mental acts performed in response to an obsession or according to rigid rules. These actions are intended to reduce anxiety or prevent a feared event, even though they may not logically connect to the feared outcome. The individual often experiences temporary relief from distress through these ritualistic responses despite their lack of practical relevance to the obsessive fears.

Cognitive Behaviour Therapy (CBT) is widely recognised as a treatment option in both the US and UK National Treatment Guidelines (National Institute for Health and Care Excellence, 2009; American Psychiatric Association, 1993). There is strong evidence supporting CBT's effectiveness in treating, preventing relapse, and managing depression and anxiety (Embling, 2002; Fava et al., 1998; Paykel et al., 1999; Thase, 1997).

However, despite this evidence, there has been limited progress in assessing CBT's effectiveness in low and middle-income countries. CBT may require adaptation in non-Western cultures, as it involves exploring and modifying automatic thoughts and core beliefs (Padesky and Greenberger, 1995).

Preliminary research suggests that treatment manuals based on fundamental CBT principles are effective (Husain et al., 2013; Rahman et al., 2008; Sumathipala et al., 2008; Araya et al., 2003). In Pakistan, an adapted version of CBT for depression was conducted, demonstrating its effectiveness in primary care settings (Naeem et al., 2011). Similarly, a pilot study was conducted on brief culturally adapted cognitive behaviour therapy for obsessive-compulsive disorder (Aslam et al. 2015).

This study aims to conduct a randomised controlled trial using brief culturally adapted cognitive behaviour therapy for obsessive-compulsive disorder in Pakistan, as limited research is available on this aspect. Conducting this trial can provide valuable data on the effectiveness of culturally adapted CBT in the Pakistani cultural setting, informing both local and international practices.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants aged 18 years or above
  • Participants with at least an elementary level of reading and writing
  • Clinical diagnosis of Obsessive Compulsive Disorder, either alone or comorbid with depression or anxiety

Exclusion criteria

  • Participants with excessive use of alcohol or drugs (using ICD-10 RDC for alcohol or drug abuse or dependence)
  • Those with significant cognitive impairment (for example, intellectual disability or dementia)
  • Or those with OCD comorbid active psychosis

Treatment and study plan

Brief culturally adapted cognitive behaviour therapy (CaCBT)

Other

The intervention will focus on psychoeducation, symptom management, Exposure and Response prevention (ERP), thought distraction techniques, relaxation exercises, detection of mood and thoughts, cognitive errors, changing negative thinking, behavioural activation, problem solving, improving relationships and communication skills, Thought diaries and progress diary.

Primary outcomes

  1. Efficacy of brief culturally adapted cognitive behaviour therapy (CaCBT) for OCD

    Time frame: 6 weeks

    By comparing pre- and post-treatment OCD scores measured through the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS).

  2. Acceptability of the brief culturally adapted cognitive behaviour therapy (CaCBT) for OCD

    Time frame: 6 weeks

    Feedback will be taken from both patients and their family members, who will be trained as co-therapists, to evaluate their satisfaction with the therapy.

Secondary outcomes

  1. Reduction in depression and anxiety associated with OCD

    Time frame: 6 weeks

    By comparing pre- and post-treatment depression and anxiety scores measured through the Hospital Anxiety and Depression Scale (HADS).

  2. Reduction in functioning decline associated with OCD

    Time frame: 6 weeks

    By comparing pre- and post-treatment scores on the Brief Disability Questionnaire (BDQ).

Study contacts

Contact information is provided by the study sponsor or research team.

Muhammad Aslam

CONTACT

[email protected]

+92 301 7170139

Sponsors and collaborators

Lead sponsor

Pakistan Association of Cognitive Therapists

Other

Registry information

Official study title

Brief Culturally Adapted Cognitive Behaviour Therapy (CaCBT) for Obsessive-Compulsive Disorder: A Randomised Controlled Trial From Pakistan

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Nov 18, 2025
Registry last updated
Nov 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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