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Completed

NCT Number: NCT04857541

Breathing Performance of Healthy Young Adult

The study will recruit subject of healthy adult, COPD-like patient and patient with COPD to investigate the difference of respiratory performance. We will measure the body composition, respiratory muscle force, pulmonary function and performance of voluntary cough. The muscle thickness of abdominal muscle and diaphragm, assessment of diaphragm during different breathing pattern and the muscle activation during voluntary cough will also being determined. We hypothesized that there will be a significantly different between three group on the performance of voluntary cough, and the correlation between each variable will be further investigated.

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Key information

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Cheng Kung University Hospital

Tainan, 704, Taiwan

About this study

The specific aims of the study are:

  • difference of respiratory muscle performance between three groups
  • the correlation between respiratory symptom and pulmonary functional test
  • difference of functional respiratory performance (peak cough flow of voluntary cough) between three groups
  • muscle activation of abdominal muscle and diaphragm during performing voluntary force
  • performance of diaphragm under different breathing load

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

  • Health subject

Inclusion criteria

  • aged 20 years or above
  • currently not being diagnosis as COPD
  • less than 4 times/week of aerobic exercise
  • COPD-like subject

Inclusion criteria

  • aged 20 years or above
  • currently not being diagnosis as COPD
  • presented of COPD symptoms (coughing, sputum production and dyspnea), last for 3 months and more than 2 years
  • score more than 1 on modified Medical Research Council (mMRC) or COPD Assessment Test (CAT)
  • COPD subject

Inclusion criteria

  • aged 20 years or above
  • currently being diagnosis as COPD
  • haven't participated in any pulmonary rehabilitation program in the past three months

Exclusion criteria

  • Untreated comorbidities for COPD
  • Postural asymmetries (Scoliosis, length discrepancy of the lower limbs or other previous surgical history of spine)
  • Chronic nonspecific lumbopelvic pain
  • Gynecological or abdominal surgery in the previous year
  • Pregnancy or post-delivery in the previous 6 months
  • Neurological or inflammatory disorders
  • Any conditions that may interfere with the data collection

Treatment and study plan

Primary outcomes

  1. Peak cough flow

    Time frame: baseline

    Peak coughing velocity of voluntary cough in liter/second

Secondary outcomes

  1. Respiratory muscle force

    Time frame: baseline

    MIP/MEP in cmH2O

  2. Pulmonary function test

    Time frame: baseline

    PEF/MVV in liter/min

  3. Pulmonary function test

    Time frame: baseline

    FEV1/FVC/VT in liter

  4. Pulmonary function test

    Time frame: baseline

    MVV rate in breaths/min

  5. Muscle thickness during voluntary force

    Time frame: baseline

    tRA/tEO/tIO/tTrA/tD in millimeter

  6. Muscle activation during voluntary force

    Time frame: baseline

    aURA/aLRA/aEO/aIOTrA/aD (all the data will be collected through surface EMG and will be presented as maximal voluntary contraction in %)

  7. Diaphragm assessment

    Time frame: baseline

    QB_ex/DB_ex/Sniff_ex in millimeter

  8. Diaphragm assessment

    Time frame: baseline

    QB_slope/DB_slope/Sniff_slope in cm/s

Sponsors and collaborators

Lead sponsor

National Cheng-Kung University Hospital

Other

Registry information

Official study title

Investigation of Breathing Performance of Healthy Young Adult

Important dates

Study start
2021
Primary completion
2021
Study completion
2022
First posted
Apr 23, 2021
Registry last updated
Jun 10, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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