Breath Analysis to Diagnose Lung Cancer

Determination of volatile organic compounds to discriminate patients with lung cancer from healthy smokers and non-smokers healthy subjects.

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Key information

Conditions

Lung Cancer Disease Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Calmette, CHU, Lille, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with histologically proven lung cancer

Controls:

healthy smoker or non-smoker subjects
without respiratory diseases excepted chronic obstructive pulmonary disease.

Exclusion criteria

history of cancer other than lung cancer within 5 years before inclusion
oral or facial malformation
incomprehension of maneuvers for the collection

Treatment and study plan

Collection of volatile organic compounds during exhalation

Device

The volatile organic compounds (VOCs) are collected in sorbents at rest and at the end of exhalation according to the concentration of carbon dioxide using ReCIVA breath sampler.

The identification of the VOCs will be done by chromatography (Gas Chromatography Mass Spectrometry GC-MS)

Primary outcomes

Discriminating power of VOCs

Time frame: 34 months

Discriminating power of VOCs using discriminant analyzes using innovative data mining methods based on multi-objective combinatorial optimization.

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Collaborators

Institut MinesTelecom (IMT)
Institut National de Recherche en Informatique et en Automatique
Institut Pasteur de Lille

Registry information

Official study title

Analysis of Volatile Organic Compounds in Exhaled Air as a Diagnostic Tool for Thoracic Cancers

Acronym: CATOCOV

Important dates

Study start: 2019
Primary completion: 2024
Study completion: 2024
First posted: Aug 15, 2017
Registry last updated: Apr 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed