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Completed

NCT Number: NCT02186639

Breath Analysis in Chronic Obstructive Lung Disease (COPD)

To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Completed

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Key information

Conditions

COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Zurich, Pulmonary Division

Zurich, 8091, Switzerland

About this study

This is an observational study comparing the volatile organic compounds (VOCs) in exhaled breath between COPD patients and matched control subjects (age, gender, smoking-state). 40 COPD patients (20 non-frequent, 20 frequent exacerbators) and 40 matched controls will be examined by SESI-MS on the composition of exhaled breath for identification of COPD specific markers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • confirmed COPD GOLD stage I-IV, based on a post-bronchodilator spirometry (FEV1/FVC < 0.7) performed within the last 6 months
  • age between 18 and 80 years at study entry
  • healthy controls: normal spirometry

Exclusion criteria

  • COPD exacerbation within the last 6 weeks
  • any lung disease other than COPD
  • acute inflammatory disease (e.g. common cold) within the last 6 weeks
  • acute or chronic hepatic disease
  • renal failure or renal replacement therapy

Treatment and study plan

Primary outcomes

  1. COPD-specific mass spectrometric exhaled breath pattern

    Time frame: baseline

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

  • Swiss National Science Foundation

Registry information

Official study title

Exhaled Breath Analysis in Patients With COPD by Secondary Electrospray Ionization - Mass Spectrometry (SESI-MS)

Important dates

Study start
2014
Primary completion
2016
Study completion
2017
First posted
Jul 10, 2014
Registry last updated
Mar 29, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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