Department of Food and Drugs, University of Parma
Parma, 43125, Italy
NCT Number: NCT03710200
Wheat is one of the most important crop for humans and it represents a source of multiple nutrients, dietary fiber and bioactive compounds, especially if consumed as wholegrain. Several studies have suggested that Triticum heritage varieties could present a healthier and better nutritional profile than modern wheats, by providing more vitamins, minerals and nutraceutical compounds. Although the effect of ancient grain consumption have been partially investigated in both animal and human studies, the potential impact of Triticum heritage varieties compared to modern ones on post-prandial glucose metabolism is still unclear. Thus, the aim of the study was to evaluate the impact on post-prandial glycaemia and insulinemia of different types of breads formulated with flours derived from mix of heritage varieties belonging to the Triticum genus selected and cultivated in specific areas of Emilia Romagna region, compared to breads made with conventional/modern wheat flours.
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Notify Me18 year–75 year
All sexes
Interventional
Not applicable
Parma, 43125, Italy
Cereal grain based products constitute a major part of the daily diet, and wheat is the most important crop for humans representing a source of multiple nutrients, dietary fiber and bioactive compounds, especially if consumed as wholegrain. Depending on its physical and chemicals properties, such as structure of grains, granular size of semolina, quantity and quality of fiber and phytochemicals, amylose/amylopectin ratio, wheat may vehicle protective effects on human health. After the Green Revolution, most of wheat species grown are hybrids, which derive from ancient wheat over the last 100 to 150 years. The main results of this revolution were the development of modern varieties characterized by higher yield, a reduced susceptibility to disease and insects, an increase tolerance to environmental stresses, a homogeneous maturation and a better gluten quality, compared to ancient wheat. At the same time, a decrease in genetic variability as well as a gradual depletion of the nutritional and nutraceutical properties of the wheat occurred. However, over the last years, the increase of diet-related chronic disease led to the nutritional improvement of wheat for ameliorating its health potential. Nowadays, the higher value of whole grains than refined grains is recognized, while the nutritional effects of ancient versus modern grains is still controversial. Generally, ancient species are higher in vitamins, such as folate, niacin and vitamin B6, as well as in minerals such as calcium, iron, magnesium and phosphor compared to modern species, however evidence linked to their real health in vivo effects is still lacking. Therefore, the aim of the present study is to evaluate the nutritional profile of eight breads made with ancient (Triticum heritage varieties) or modern grains on the plasma response of glucose and insulin.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
-generally healthy
Exclusion criteria
Bologna 00 bread made with yeast (portion corresponding to 50g available carbohydrates) +500 mL of water
Bologna 1 bread made with yeast (portion corresponding to 50g available carbohydrates) +500 mL water
Bio2 bread made with yeast (portion corresponding to 50g available carbohydrates) +500 mL water
Icarda bread made with yeast (portion corresponding to 50g available carbohydrates) +500 mL water
Bologna 1 bread made with sourdough (portion corresponding to 50g available carbohydrates) +500 mL water
109g of Bio2 bread made with sourdough (portion corresponding to 50g available carbohydrates) +500 mL water
Icarda bread made with sourdough (portion corresponding to 50g available carbohydrates) +500 mL water
Grossi bread made with sourdough (portion corresponding to 50g available carbohydrates) +500 mL water
Time frame: 2 hours (-10 and 0 -fasting-, 15, 30, 45, 60, 90, 120 minutes)
Post-prandial glycemic response (iAUC)
Time frame: 2 hours (-10 and 0 -fasting-, 15, 30, 45, 60, 90, 120 minutes)
Post-prandial response for insulin (iAUC)
Time frame: 2 hours (-10 and 0 -fasting-, 15, 30, 45, 60, 90, 120 minutes)
maximum value of postprandial glucose and insulin response
Time frame: 2 hours
differences in subject-rated satiety using a 100cm visual analog scale
Time frame: 2 hours
differences in subject-rated gastrointestinal symptom questionnaire
University of Parma
Other
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