BRCA Mutations in Latinas

BACKGROUND:

• Mutations in the BRCA1 and BRCA2 genes predispose to breast and ovarian cancer, and are increasingly recognized in prostate and pancreatic cancers.
• Basal/ Triple negative breast cancer is associated with BRCA mutations in some ethnicities.However the link between BRCA gene mutations and Basil/ triple negative disease in Hispanic/ Latino women is not known.
• Common recurrent mutations in BRCA1 and BRCA2 exist in Hispanic/ Latino communities.
• New therapies such as PARP inhibitors may be particularly effective in BRCA mutation carriers.
• Therefore a unique opportunity exists to identify women in this underserved minority that may be eligible for and benefit from new targeted therapies.

OBJECTIVES:

• The primary objective is to collect saliva samples and histology data from up to 2000 Hispanic/ Latino subjects with breast cancer as a source of DNA, and to analyze the BRCA1 and BRCA2 genes..

ELIGIBILITY:

• All Hispanics females, over the age of 18, with breast cancer will be eligible.

DESIGN:

• Natural history study of 2000 Hispanic/Latino women with breast cancer, 1000 with triple

negative disease, 1000 without.

• Obtain clinical pathology reports and relevant history data on all subjects.
• Analyze recurrent BRCA1 and BRCA2 mutations

• INCLUSION CRITERIA:
• Patient must be self-identified of Hispanic/Latino origin.
• Patients must have histologically or cytologically confirmed diagnosis of breast cancer.
• Age greater than or equal to 18 years.
• Ability to understand and the willingness to sign a written informed consent document.
• Must be willing and able to provide a saliva sample, answer questionnaire data online or complete a paper questionnaire, and request a copy of their pathology report.

Exclusion criteria

• Males and subjects under the age of 18.