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OpenTrials
Completed

NCT Number: NCT01350427

Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways

This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.

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Key information

Conditions

Healthy

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of São Paulo - School of Physical Education and Sports

São Paulo, 05508-030, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Sedentaries
  • Must be able to exercise
  • Must be able to swallow tablets

Exclusion criteria

  • Use of nutritional supplements
  • Use of anti-inflammatory drugs

Treatment and study plan

Leucine supplementation

Dietary Supplement

1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine

BCAA supplementation

Dietary Supplement

1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine

Alanine supplementation

Dietary Supplement

1 bout of resistance exercise and supplementation of 9.6 g of alanine

Primary outcomes

  1. Protein synthesis

    Time frame: 1 hour

    Phosphorylation of proteins involved in protein synthesis

  2. Protein degradation

    Time frame: 1 hour

    Expression of protein involved in proteolytic pathway

  3. Inflammation

    Time frame: 1 hour

    Expression of systemic and muscular cytokines

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
May 9, 2011
Registry last updated
Feb 25, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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