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Completed

NCT Number: NCT06848712

Brain Structural Abnormalities in Patients With Vertigo

Introduction: Dizziness is one of the most common complaints in medical practice and is associated with various underlying conditions, including neurological, otolaryngological, and psychological disorders. Preliminary imaging studies like CT, cervical spine X-rays, and carotid/vertebral artery ultrasound, aids in precise diagnosis and targeted therapeutic decisions. MRI is one of the most effective imaging modalities currently available for examining the brain.

Purpose: To identify structural brain changes linked to vertigo, explore pre-MRI diagnostic approaches, and evaluate treatment strategies.

Methods: The study included 232 patients with vertigo and 232 control subjects. MRI results were categorized, and pre-MRI examinations, symptoms, and treatments were analyzed. Statistical comparisons were conducted using chi-square and t-tests, with significance set at p<0.05.

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Key information

Conditions

Vertigo Ear Diseases Infections Labyrinth Diseases MRI Nervous System Diseases Neurologic Manifestations Nose Diseases Otorhinolaryngologic Diseases Paranasal Sinus Diseases Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Respiratory Tract Infections Signs and Symptoms Sinusitis Vestibular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Szent Margit Hospital

Budapest, 1032, Hungary

About this study

Vertigo is a prevalent symptom with multiple underlying etiologies, including neurological, vascular, and musculoskeletal causes. Despite its high prevalence, the exact structural brain abnormalities associated with vertigo remain unclear. This observational study aims to assess brain MRI findings in patients with vertigo and compare them to a control group without vertigo symptoms. The study also evaluates pre-MRI diagnostic procedures, such as vertebral/carotid ultrasound and cervical spine X-rays, to identify potential vascular and musculoskeletal contributors to vertigo. The results may provide insights into the structural brain changes linked to vertigo and help refine diagnostic and treatment strategies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years
  • Reported dizziness (vertigo) as a primary symptom
  • Brain MRI requested by the attending physician

Exclusion criteria

  • Prior neurological disease or disorder (other than vertigo/dizziness in the vertigo group)
  • MRI contraindications (e.g., pacemaker, metal implants, claustrophobia)

Treatment and study plan

Observational study - no intervention

Other

This is an observational study evaluating brain structural abnormalities in post-COVID headache patients. No experimental intervention is applied.

Primary outcomes

  1. Occurrences With Specific Structural Brain Abnormalities Observed on MRI

    Time frame: From September 2020 to December 2022

    Brain MRI findings were analyzed to compare the occurrences of structural abnormalities between vertigo patients and control participants. The most commonly assessed abnormalities included white matter lesions, lacunar infarcts, Circle of Willis variations, and sinusitis. The occurrences (number and percentage) of these findings in each group will be compared using chi-square tests.

Secondary outcomes

  1. Occurrences of associated symptoms in vertigo patients

    Time frame: From September 2020 to December 2022

    The study evaluated the occurrences of associated symptoms, including headache, imbalance, visual disturbances, and psychological symptoms (anxiety and depression). Each symptom's occurrences (number and percentage) will be reported separately.

  2. Occurrences of pre-MRI diagnostic procedures in vertigo patients

    Time frame: From September 2020 to December 2022

    The study assessed the occurrences of patients with vertigo undergoing pre-MRI diagnostic procedures, including carotid/vertebral ultrasound and cervical spine X-rays. Each procedure's occurrences (number and percentage) will be reported separately.

  3. Occurrences of post-MRI diagnoses in vertigo patients

    Time frame: From September 2020 to December 2022

    The study analyzed the most common diagnoses after MRI, including vestibular migraine, benign paroxysmal positional vertigo (BPPV), and vascular dizziness. Each diagnosis's occurrences (number and percentage) will be reported separately.

  4. Occurrences of treatment strategies applied

    Time frame: From September 2020 to December 2022

    The study evaluated the most frequent treatment strategies, including physical therapy, pharmacological treatment (e.g., betahistine), and lifestyle modifications. Each treatment's occurrences (number and percentage) will be reported separately.

Sponsors and collaborators

Lead sponsor

University of Pecs

Other

Registry information

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Feb 27, 2025
Registry last updated
Feb 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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