Brain Reaction to Treatment of Nicotine Dependence

The purpose of the study was to determine how the treatments for cigarette craving work.

Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

Completed

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Key information

Conditions

Nicotine Dependence Chemically-Induced Disorders Mental Disorders Substance-Related Disorders Tobacco Use Disorder

Age range

21 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

VA Greater Los Angeles Healthcare System, West LA

West Los Angeles, California, 90073, United States

About this study

PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Heavy smoker, more than one pack per day
Free of medical conditions or medications that affect brain activity
Not pregnant

Exclusion criteria

Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions

Treatment and study plan

Zyban

Drug

Primary outcomes

2-FA PET scan results

Time frame: Within the first few weeks of study initiation

Brain activity and activation in response to cigarette-related cues

Sponsors and collaborators

Lead sponsor

US Department of Veterans Affairs

Fed

Registry information

Official study title

Neural Substrates of Treatment for Nicotine Dependence

Important dates

Study start: 2002
Primary completion: 2007
Study completion: 2011
First posted: Apr 15, 2005
Registry last updated: Apr 9, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed