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Completed

NCT Number: NCT07635615

Brain Oscillations and Neural States

The study aims to investigate, through the use of electroencephalography (EEG), instantaneous brain states, namely rapid oscillations of the brain's electrical activity, and their relationship with behavior and brain functions. The study will focus on three main objectives: (1) establishing a relationship between brain oscillations and behavior; (2) establishing a relationship between brain oscillations and brain functions, in terms of neural responsiveness; and (3) identifying the different phases of brain oscillations and investigating any related modulations of behavior and brain functions.

PHAROS will combine EEG with transcranial magnetic stimulation (TMS) to investigate and modulate brain states non-invasively.

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Key information

Conditions

Transcranial Magnetic Stimilation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

IRCCS San Camillo Hospital, Venice, Italy

Venice-Lido, Italy

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults

Exclusion criteria

  • Left-handedness (assessed through the Oldfield test)
  • Diagnosis of neurological or psychiatric disorders
  • Vision problems that prevent reading, not correctable with lenses
  • Diagnosis of substance dependence on drugs or alcohol
  • Presence of hearing aids/prostheses
  • Diagnosis of epilepsy or family history up to the second degree with it
  • Episodes of febrile convulsions or recurrent fainting
  • Head trauma
  • Presence of surgical clips or metal implants in the head
  • Diagnosis of heart disease
  • Presence of a cardiac pacemaker or artificial heart valve
  • Presence of hearing aids/prostheses
  • Hearing problems or tinnitus
  • Vision problems not corrected with lenses (such as color blindness)
  • Taking tricyclic antidepressant medications
  • Taking neuroleptic medications
  • Diagnosis of headache or migraine
  • Taking more than 3 alcoholic units in the last 24 hours
  • Taking 2 or more cups of coffee or caffeine from other sources in the last 2 hours

Treatment and study plan

Behavioral Treatment

Other

Imagining an abduction movement of the right index finger

Primary outcomes

  1. Motor-evoked potential

    Time frame: Baseline

    Motor-evoked potentials (MEPs) will be recorded from the right index-finger abductor muscle following single-pulse TMS delivered over the primary motor cortex. MEPs will be used as an index of corticospinal excitability. The main outcome measure will be the peak-to-peak MEP amplitude, calculated as the difference between the maximum and minimum EMG signal within the post-stimulation time window.

  2. Motor-evoked potential

    Time frame: Immediately after the intervention

    Motor-evoked potentials (MEPs) will be recorded from the right index-finger abductor muscle following single-pulse TMS delivered over the primary motor cortex. MEPs will be used as an index of corticospinal excitability. The main outcome measure will be the peak-to-peak MEP amplitude, calculated as the difference between the maximum and minimum EMG signal within the post-stimulation time window.

  3. TMS-evoked potential

    Time frame: Baseline

    TMS-evoked potentials (TEPs) will be recorded using EEG following single-pulse TMS. TEPs will be used as an index of cortical responsiveness to stimulation. The main outcome measures will be the amplitude and latency of the main TEP components within predefined post-stimulation time windows.

  4. TMS-evoked potential

    Time frame: Immediately after the intervention

    TMS-evoked potentials (TEPs) will be recorded using EEG following single-pulse TMS. TEPs will be used as an index of cortical responsiveness to stimulation. The main outcome measures will be the amplitude and latency of the main TEP components within predefined post-stimulation time windows.

Sponsors and collaborators

Lead sponsor

IRCCS San Camillo, Venezia, Italy

Other

Registry information

Official study title

Relationship Between Brain Oscillations and Neural States

Acronym: PHAROS

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 9, 2026
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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