Multimodal Imaging Evaluation
OtherFunctional connectivity analysis of brain networks based on functional magnetic resonance imaging (fMRI) technology
Not Yet Recruiting
NCT Number: NCT07308249
Brain Network fMRI Analysis in Proprioceptive Training for Chronic Low Back Pain
Through longitudinal analysis of dynamic changes in DMN functional connectivity before and after sensory training intervention, combined with pain behavioral and functional improvement indicators, this study systematically reveals the central neural remodeling patterns in CNLBP and establishes an objective efficacy evaluation system based on multimodal imaging.
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Conditions
Age range
18 year–60 year
Sex eligibility
All sexes
Study type
Observational
About this study
This phase of the research aims to elucidate the neuroplasticity mechanisms induced by CNLBP treatment, providing a theoretical basis for the future development of personalized rehabilitation protocols based on brain network subtypes, ultimately achieving the clinical goals of reducing pain recurrence rates and improving long-term prognosis in patients.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Age between 18 and 60 years old;
- Current or past low back pain lasting more than three months; ③ No abnormal sensation or reflex abnormalities in the lower limbs; ④ Able to commit to participating in training three times per week for three months.
Exclusion criteria
- Fractures, dislocations, structural abnormalities, prior surgery, metal implants, or lumbar disc herniation;
- Comorbidities such as severe cardiovascular diseases, neurological disorders, osteoporosis, or metabolic diseases; ③ Low back pain caused by visceral diseases;
- VAS score (range 1-10) exceeding 8 points;
- Pregnant or lactating women; ⑥ Symptoms of nerve root irritation; ⑦ Recent participation in core stability training.
Treatment and study plan
Primary outcomes
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VAS
Time frame: After 4 weeks of treatment
The Visual Analogue Scale (VAS) was used to assess the severity of low back pain, with 0 indicating no pain and 10 indicating unbearable severe pain.
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JOA
Time frame: After 4 weeks of treatment
The Japanese Orthopaedic Association (JOA) efficacy assessment criteria for low back disorders were applied to evaluate lumbar function.
Secondary outcomes
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MRI
Time frame: After 4 weeks of treatment
Magnetic resonance imaging was used to assess the effects of treatment on brain networks.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Other
Registry information
Official study title
Research on the Application of Brain Network Functional Connectivity Analysis Based on Functional Magnetic Resonance Imaging in Proprioceptive Training for Chronic Non-Specific Low Back Pain
Important dates
- Study start
- 2025
- Primary completion
- 2028
- Study completion
- 2028
- First posted
- Dec 29, 2025
- Registry last updated
- Dec 29, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.