Skip to main content
OpenTrials
Completed

NCT Number: NCT02409914

Brain Metabolism in Polycystic Ovary Syndrome

The purpose of this study is to investigate whether higher insulin resistance in young women with Polycystic ovary syndrome (PCOS) is associated with reduced cerebral metabolic rate of glucose (CMRglu). Brain volumes using magnetic resonance imaging (MRI) and quantitative cerebral glucose uptake using dynamic positron emission tomography (PET) were obtained.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Insulin Resistance Glucose Metabolism Disorders Hyperinsulinism Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–35 year

Sex eligibility

Female

Study type

Observational

About this study

MRI and FDG PET scan for each participant were obtained within an average time frame of 3 weeks. Isulin resistance were assessed with the updated homeostasis model assessment (HOMA2-IR).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of PCOS
  • Age ≤ 35 y
  • BMI ≤ 35

Exclusion criteria

  • Taking medications for diabetes or insulin-sensitizing drugs
  • Drug addictions
  • Psychiatric illness
  • Smoking
  • Overt evidence of heart, liver or renal disease

Treatment and study plan

Primary outcomes

  1. Global Brain Glucose PET Uptake

    Time frame: Single point in time (day 1)

    Global brain glucose uptake was quantified using FDG with dynamic positron emission tomography.

  2. Brain MR Volumes

    Time frame: Single point in time (day 2)

    T1-weighted brain MR images were obtained on a 1.5 Tesla scanner. Regional volumes were determined using FreeSurfer Suite 5.0 software.

  3. Insulin Resistance (HOMA2-IR)

    Time frame: Single point in time (day 1 during the FDG PET)

    The homeostasis model assessment computational method was used to estimate insulin resistance (HOMA2-IR) from fasting plasma glucose and insulin. The HOMA2-IR is the reciprocal of insulin sensitivity (%S), as a percentage of a normal reference population (normal young adult). A higher score indicates a lower insulin sensitivity.

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Registry information

Official study title

Brain Metabolism in Women With Polycystic Ovary Syndrome: a PET/MRI Study

Important dates

Study start
2010
Primary completion
2014
Study completion
2014
First posted
Apr 7, 2015
Registry last updated
May 2, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.