Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder

Inclusion criteria

• General: pre-pubertal (e.g. Tanner stage 1 or 2)
• age 7-12 inclusive
• signed consent/assent
• parent communicates sufficiently in English
• Has ADHD as determined by parent interview
• ADHD-Rating Scale-5 total score (interview with parent) of 1.5 SD > age/sex norms
• Youth with CD or severe ODD: CD or ODD + 2 symptoms of CD

Exclusion criteria

• major neurological/medical illness
• history of head injury
• fetal exposure to alcohol/drugs;
• diagnosis of major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, generalized anxiety, social phobia, Tourette's Disorder, PTSD, autism spectrum disorder) current suicidal ideation or past history of suicide attempt
• Wechsler Abbreviated Scale of Intelligence (WASI) score <75; 7)
• current treatment with stimulants (prior or current treatment with non-stimulants is permitted, but participants must be off medication for 2 weeks at baseline; youth who had a past, brief stimulant medication exposure of no more than about a month, and not within the past 6 months may be included .)
• current or past alcohol/drug use (interview; urine toxicology)
• psychological or medical condition which precludes being in the scanner (e.g., claustrophobia, morbid obesity)
• metal in the body that cannot be removed
• visual disturbances that may impair task performance
• precocious puberty (e.g. Tanner stage >2).