Brain Imaging of Psychotherapy for Depression

The goal of the proposed research is to examine the neural correlates of depressive symptom reduction in individuals with major depressive disorder using functional magnetic resonance imaging (fMRI), and to compare results to those obtained from a nondepressed control group.

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Key information

Conditions

Major Depressive Disorder Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Age range

21 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Duke-UNC Brain Imaging and Analysis Center

Durham, North Carolina, 27710, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For group 1: Diagnosis of current depression and no other current Axis I psychiatric disorder
For group 1: Hamilton Depression Rating Scale score of 15 or greater

Exclusion criteria

A history of serious head injury or neurological disease or psychosis
Current use of psychoactive medications
Factors that could affect MRI safety including current or planned pregnancy
For group 2: current Axis I psychiatric disorder, as assessed by structured clinical interview

Treatment and study plan

Brief Behavioral Activation Treatment for Depression

Behavioral

Weekly individual therapy sessions

Primary outcomes

Hamilton Depression Inventory

Time frame: three times over 12 weeks
Functional Magnetic Resonance Imaging

Time frame: twice in 12 weeks

Sponsors and collaborators

Lead sponsor

University of North Carolina, Chapel Hill

Other

Registry information

Official study title

Brain Imaging of Psychotherapy for Depression (Includes, "Reward System Recovery Following Behavioral Activation Therapy in Depression")

Important dates

Study start: 2006
Primary completion: 2008
Study completion: 2008
First posted: Feb 7, 2008
Registry last updated: Oct 8, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed