Brain Genomics Superstruct Project

The purpose of this study is to explore the effects of genes and genetic variation on brain structure and function. Investigators at Harvard plan to explore the relationship between candidate genes that affect cognitive performance and brain structure/function. Since brain phenotypes reflect more proximal sequelae of gene activity, neuroimaging measures may show greater sensitivity than cognitive performance to measure gene effects.

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Key information

Conditions

Autism Spectrum Disorders Autism Spectrum Disorder Child Development Disorders, Pervasive Mental Disorders Neurodevelopmental Disorders

Age range

13 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

13 years or older
Subject must have a current DSM-IV diagnosis of high functioning ASD, based on past evaluations at the Bressler Clinic.
Subjects must have a level of understanding sufficient to communicate intelligently with the investigator and study coordinator, and to cooperate with all tests and examinations required by the protocol.
Each subject must understand the nature of the study. The subject must sign an IRB approved informed consent.

Exclusion criteria

IQ < 70 bassed on evaluation in the Bressler Clinic.
Contraindication to MRI including presence of metal or surgical devices (plates, implants, braces or other items).
Neuropsychiatric conditions (such as dementia) which sufficiently impair cognition such that a surrogate consent would be required.
Neurological disorders associated with gross brain pathology (other than atrophy), e.g., stroke, tumors, or demyelinating diseases.
Pregnancy.

Treatment and study plan

Primary outcomes

Neuroimaging phenotype

Time frame: 1 day

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

Harvard University

Registry information

Important dates

Study start: 2011
Primary completion: 2015
Study completion: 2015
First posted: Mar 13, 2012
Registry last updated: Jun 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed