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OpenTrials
Completed

NCT Number: NCT03974282

Brain Function and Decision-Making

This study is about how brain function and structure is different between two universities. Participant in this project will contribute to a better understanding of how universities affect the brain.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Virginia Commonwealth University

Richmond, Virginia, 23298, United States

About this study

Some study details are purposely omitted at this time to preserve scientific integrity. Now that the study is completed, full details are included below.

The true purpose of this study was to investigate the psychometric properties of the two computer tasks that participants completed. Specifically, researchers wanted to know if they would be able to accurately measure motivated empathy. To better understand this, participants were asked to rate images of people expressing pain and were told that these were either students from their university or students from a different university. This was not the case. The faces shown were random images produced for a research study.

Researchers also wanted to know if they could accurately measure moral decision making and how those judgments relate to aggression. To examine this, participants were asked whether various scenarios were immoral and then asked about aggressive tendencies.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Undergraduate students aged 18 - 35 years of age
  • No current or regular use of prescribed or illicit psychoactive drugs
  • Free of major health problems (e.g., diabetes, HIV, Parkinson's disease)
  • Free of a neurological or psychiatric disorders
  • No current drug abuse (e.g., recreational drug use, average alcohol intake in excess of 4 drinks per day).
  • Right hand dominant
  • Free of claustrophobia
  • Free of pregnancy or suspected pregnancy
  • Absent MRI risk factors (e.g., implanted medical device, body mass index > 35, braces)
  • Free of medical conditions that render individuals with overly sensitive hearing
  • No colorblindness

Exclusion criteria

  • Not meeting the inclusion criteria listed above.

Treatment and study plan

Psychological task

Behavioral

Participants will complete a psychological task that evokes antisocially- and prosocially-motivated empathic responding

Primary outcomes

  1. Change in Prefrontal Cortex Brain Activity Assessed by fMRI

    Time frame: Baseline to 3 hours

    Blood-Oxygen-Level-Dependent signal change in the cognitive empathy brain network will be assessed using functional MRI

  2. Change in Accuracy of Empathic Pain Judgments

    Time frame: Baseline to 3 hours

    Difference in pain judgment scores rated from 1 (low) to 4 (high) between antisocial vs prosocial empathy trials

Sponsors and collaborators

Lead sponsor

Virginia Commonwealth University

Other

Collaborators

  • National Center for Advancing Translational Sciences (NCATS)

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jun 4, 2019
Registry last updated
Feb 6, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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