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Completed

NCT Number: NCT02741622

Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression.

The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

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Key information

Conditions

Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

St.Olavs university Hospital, Departement of Østmarka

Trondheim, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Moderate or severe depression (ICD10: F32-F33)

Exclusion criteria

  • Bipolar disorder.

Treatment and study plan

High aerobic intensity training (HIT)

Behavioral

One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)

Long slow distance training (LSD)

Behavioral

One training session, long slow distance training (LSD) at 70 % of the HRmax

Primary outcomes

  1. Change in serum brain derived neurotropic factor (BDNF)

    Time frame: 15 minutes before exercise to 5> minutes after exercise.

    To measure serum BDNF levels, blood samples will be taken before and after each workout session.

Secondary outcomes

  1. Change in affective symptoms

    Time frame: 15 minutes before exercise to 15> minutes after exercise.

    The positive and negative affect schedule (PANAS) .

  2. Change in state of anxiety.

    Time frame: 15 minutes before exercise and 15> minutes after exercise.

    A short form of state trait anxiety inventory for adults (STAI) is used to detect their state of anxiety.

  3. Change in subjective exercise experience

    Time frame: 15 minutes before exercise to 15> minutes after exercise.

    The Subjective exercise experience scale (SEES).

  4. Maximal oxygen uptake

    Time frame: Baseline

  5. Maximal Heart rate

    Time frame: Baseline

Sponsors and collaborators

Lead sponsor

St. Olavs Hospital

Other

Collaborators

  • Norwegian University of Science and Technology

Registry information

Official study title

Effects of Aerobic Exercise Intensity on Affective States and Brain Derived Neurotropic Factor in Patients With Depression

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Apr 18, 2016
Registry last updated
Dec 4, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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