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OpenTrials
Completed

NCT Number: NCT03117478

Brain and Mindfulness

The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.

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Key information

Conditions

Healthy

Age range

25 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Le Vinatier

Bron, 69500, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age : 25-70
  • Being affiliated to a social security system.
  • Motivated to participate in this study.

Exclusion criteria

  • Medication acting on the central nervous system
  • Opioids, Antidepressive Agents.
  • Actual or previous neurological or psychiatric illnesses
  • Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.
  • Not having a personal or family history of epilepsy
  • Alcohol or drugs consumption 2 days before or during the study.

Treatment and study plan

Magneto-encephalography (MEG)

Other

Magneto-encephalography

Electro-encephalography (EEG)

Other

Electro-encephalography

Functional magnetic resonance imaging (fMRI)

Other

Functional Magnetic Resonance Imaging

Anatomical Magnetic Resonance Imaging (aMRI)

Other

Anatomical Magnetic Resonance Imaging

Meditation

Other

Meditation

Primary outcomes

  1. Anatomical MRI scan

    Time frame: Day 1

    Brain structure

  2. Functional MRI scan

    Time frame: Day1

    Brain activation: Haemodynamic response - BOLD signal.

  3. EEG

    Time frame: Day 1

    Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT^2/Hz

Secondary outcomes

  1. Behavioral measure : Accuracy of the performed task actions

    Time frame: Day 1

    Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Accuracy of the performed task actions: number of errors and hits

  2. Psychophysics: Pain threshold

    Time frame: Day 1

    Pain threshold: The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. The temperature in degrees Celcius at which heat becomes painful for a recipient.

  3. Psychophysiology : Respiration

    Time frame: Day 1

    Respiration rate: breaths/minute

  4. Subjective experience of the participant

    Time frame: Day 1

  5. Studies biomarkers of inflammation

    Time frame: Day 1

    area of the inflamed site in mm^2, obtained by automatic image processing of a photography

  6. Behavioral measure : Speed of the performed task actions

    Time frame: Day 1

    Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Speed of the performed task actions: in ms.

  7. Psychophysiology : Heart

    Time frame: Day 1

    Heart Rate: pulses/minute

  8. Psychophysiology : Heart rate variability

    Time frame: Day 1

    Heart rate variability (HRV): Using an electrocardiogram, the variation in the beat-to-beat interval; measured in ms.

  9. Psychophysiology : Muscles

    Time frame: Day 1

    Electromyography (EMG): Recording the electrical activity produced by muscles; measured in mV.

  10. Psychophysiology : Eyes

    Time frame: Day 1

    Eye gaze position: relative to center of the screen, in imm

  11. Psychophysiology : Pupillar response

    Time frame: Day 1

    Pupillar response: pupil diameter, in mm.

  12. Electrogastrogram

    Time frame: Day 1

    Recording the electrical signals that travel through the stomach muscles and control the muscles' contractions (waves/minute)

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

The Impact of Meditation Practice on Attention and Emotion Regulation :Studies on Neural Correlation in Brain Imagery and Biomarkers of Stress and Inflammation

Acronym: MEDITATION

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Apr 18, 2017
Registry last updated
Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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