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OpenTrials
Completed

NCT Number: NCT03781570

Brain and Genetic Predictors of Individual Differences in Pain and Analgesia

The purpose of the study is to gain a better understanding of pain processing in the brain. Our understanding of how pain is processed in the brain is limited. We are testing for individual differences in pain perception and emotion.

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Key information

Conditions

Pain, Acute Acute Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Colorado, Boulder

Boulder, Colorado, 80309, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants must be registered in the Colorado Community Twin Sample (CTS).

Exclusion criteria

  • Not being registered in the Colorado Community Twin Sample (CTS).
  • Any MRI contraindications.

Treatment and study plan

Placebo Cream

Behavioral

In the Placebo intervention, participants are given an inert cream with instructions that it is "Prodicaine, an effective pain-relieving drug". The cream is applied to two fingers on the left hand.

Control Cream

Behavioral

In the Control intervention, participants are given an inert cream with instructions that it is "a control cream with no effects" . The cream is applied to two fingers on the left hand.

Primary outcomes

  1. Pain Rating Scores Made on a Visual Analog Scale (VAS)

    Time frame: Measured during pain tasks at a single 4 hour experimental session (within one month of screening completion).

    Self reported pain using a Visual Analogue Scale (VAS) ranging from 0-100 (with 0 representing "no pain at all" and 100 representing "most intense pain imaginable (in the context of the experiment)). Higher scores indicate more pain. 0 is the minimum value and 100 is the maximum value. This scale is used for both thermal and mechanical pain. Reported values reflect averages of VAS ratings for individual stimuli for each of thermal and mechanical pain.

Sponsors and collaborators

Lead sponsor

Trustees of Dartmouth College

Other

Collaborators

  • QIMR Berghofer Medical Research Institute

Registry information

Acronym: PAINGEN

Important dates

Study start
2018
Primary completion
2023
Study completion
2023
First posted
Dec 20, 2018
Registry last updated
Jun 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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