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OpenTrials
Completed

NCT Number: NCT02819167

Brain and Cognitive Reserve

Ischemic strokes are one of the leading causes of handicap and death in elderly people in France.

Cognitive reserve (CR) is an active model, defined as a function of lifetime intellectual activities and other environmental factors that explain differential susceptibility to functional impairment in the presence of pathology or other neurological insult. CR is estimated using variables for cognitive activity: years of education, professional status, socioeconomic status… Furthermore, brain reverse (BR) is a passive and quantitative model that depend on brain size and other quantitative aspects of the brain that explain differential susceptibility to functional impairment in the presence of pathology.

Firstly, volume and localization of ischemic strokes have a great impact on CR and BR due to brain injury. On the other hand, CR influences the severity and the expression of cognitive diseases.

The investigators realize a prospective study in order to assess the impact of CR and BR on cognitive prognosis after a right middle cerebral artery ischemic stroke in elderly patients.

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Key information

Conditions

Brain Ischemia Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Stroke Nervous System Diseases Stroke Vascular Diseases

Age range

70 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital des Charpennes

Lyon, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ≥70 years old
  • right middle cerebral artery ischemic stroke
  • hospitalized in neurovascular unit of Pierre Wertheimer hospital between January 2015 to January 2016

Exclusion criteria

  • Contraindication for MRI
  • Hemorrhagic stroke
  • Aphasia

Treatment and study plan

neurologic and neuropsychological evaluation

Other

cognitive prognosis, cognitive reserve, brain volume will be studied on patients with scale, questionnaire, magnetic resonance imaging

Primary outcomes

  1. evaluation of cognitive prognosis

    Time frame: one year post Ischemic stroke

    measure will be performed with the Mattis dementia rating scale

Secondary outcomes

  1. Volume of leucoencephalopathy

    Time frame: one year post Ischemic stroke

    measure will be performed with a MRI

  2. volume of hippocampic

    Time frame: one year post Ischemic stroke

    measure will be performed with a MRI

  3. brain injury

    Time frame: one year post Ischemic stroke

    measure will be performed with a MRI

  4. volume of ischemic stroke

    Time frame: one year post Ischemic stroke

    measure will be performed with a MRI

  5. evaluation of cognitive reserve

    Time frame: one year post Ischemic stroke

    measure will be performed with the Cognitive reserve index questionnaire

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Neuro-anatomical Correlates on Volumetric MRI on the Impact of Brain Reserve and Cognitive Reserve on Ischemic Strokes in Elderly

Acronym: BCN

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jun 30, 2016
Registry last updated
Nov 20, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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