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OpenTrials
Completed

NCT Number: NCT05513846

Brain Age and Sleep Architecture in Meditators

This is a single-center, cross-sectional study that will recruit approximately fifty seven (57) meditators and fifty one (51) controls. Individuals that have learned at least the Shambhavi Mahamudra Kriya practice and live in Massachusetts will be mailed a DREEM EEG device, and a sleepimage ring. Participants will be asked to wear the two devices while sleeping for three consecutive weekday nights (Sunday night to Thursday night) and two weekend nights (Friday and Saturday nights). While meditating during the day, participants will only wear the DREEM EEG headband. Participants will also undergo neurocognitive tests from the NIH toolbox during one virtual visit via video call. Meditators who join the study will be asked to invite a control subject to the study, matched for age and comorbidities.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Beth Israel Deaconess Medical Centre

Boston, Massachusetts, 02215, United States

About this study

Approximately one hundred and eight (108) individuals will undergo three consecutive weekday nights and two weekend nights of EEG and plethysmography recording using the DREEM headband and SleepImage rings, after answering a demographic questionnaire. Out of these 108 participants, the study will aim for 57 meditators and 51 matched controls. Only meditating participants will be asked to perform the most advanced form of meditation among the following three, which are listed from least advanced to most advanced: Shambhavi Mahamudra Kriya, Shoonya Meditation, Samyama Meditation (Breath watching). Participants will be instructed to wear the DREEM EEG headband during their practice of this meditation during each of the five days.

All participants will also be asked to undergo cognitive assessments from the NIH toolbox during a video call. The assessments from the NIH toolbox will last approximately forty-five minutes to one hour.

EEG: The participants will be mailed the DREEM devices and asked to wear them for three consecutive weekday nights and two weekend nights while sleeping. During the day, for each of these five nights, meditating participants will also be asked to wear the device while they sit still with their eyes closed, without trying to meditate, for 10 minutes. This will function as the baseline waking EEG measurement. Immediately following this, participants will be asked to perform their meditation while wearing the DREEM device for a maximum of 30 minutes.

NIH Toolbox:

This study will use select tests from the NIH Toolbox Cognition Battery and from the NIH Toolbox Emotion Battery. All of the tests together will take approximately 45 minutes to 1 hour to complete.

The selected tests from the batteries are the following:

Cognition Battery

  • Picture vocabulary test
  • List sorting working memory test
  • Picture Sequence Memory test
  • Oral reading recognition test

Emotion Battery:

  • Positive Affect CAT
  • General Life Satisfaction CAT
  • Emotional Support FF
  • Instrumental Support FF
  • Friendship FF
  • Loneliness FF
  • Perceived Stress FF

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(Meditators):

  • Previous experience with learning Shambhavi Mahamudra Kriya
  • Age 18 years or older.
  • Lives in the United States barring California

Inclusion criteria

(Controls):

  • Age 18 years or older
  • Lives in the United States barring California

Exclusion criteria

(both groups):

  • Non-English Speaking
  • Night Shift workers

Treatment and study plan

DREEM EEG Device

Device

The DREEM EEG device will be used to measure brain age.

SleepImage Ring

Device

The SleepImage ring uses plethysmography to analyze sleep architecture and cardiopulmonary coupling.

Primary outcomes

  1. Brain Age

    Time frame: Measured for 3 weekday and 3 weekend nights during the data collection period

    Brain Age will be calculated using an algorithm from the sleeping EEG. A Brain Age index score will be created for each participant based on an aggregate of the five days of sleeping EEG data. The Brain Age Index is the brain age calculated from the algorithm subtracted by the chronological age of the participant.

Sponsors and collaborators

Lead sponsor

Beth Israel Deaconess Medical Center

Other

Registry information

Acronym: BRANCH

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Aug 24, 2022
Registry last updated
Jan 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.