Brain Activity in Adults With ADHD During Neuropsychological Tasks

The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.

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Key information

Conditions

Attention Deficit Hyperactivity Disorder (ADHD) Attention Deficit Disorder with Hyperactivity Attention Deficit and Disruptive Behavior Disorders Mental Disorders Neurodevelopmental Disorders

Age range

20 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kantonsspital Aarau

Aarau, Canton of Aargau, 5001, Switzerland

About this study

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood.

The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested.

Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participant is between 20-55 years old
Participant is not pregnant

Exclusion criteria

Participant is not able to consent him/herself
Suspected or proven pregnancy
Nursing
Neurological diseases that could interfere with a diagnosis of ADHD
Psychiatric comorbidity under treatment
Previous history of psychiatric medication
Substance abuse
Intelligence quotient<75
Claustrophobia
Electrical simulator nerve or bone
Implanted medication infusion pump
Cerebral aneurysm clips
Unstable medical condition

Treatment and study plan

MRI

Device

Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency

Primary outcomes

Changes in blood oxygenation level dependency (BOLD)

Time frame: 2 hours

The study consist solely of one MRI examination performed within 2 hours.

Sponsors and collaborators

Lead sponsor

Kantonsspital Aarau

Other

Registry information

Official study title

Brain Activity and Functional Connectivity in Adults With Attention-Deficit Hyperactivity Disorder (ADHD) During Tasks of Motor Inhibition and Cognitive Switching

Important dates

Study start: 2015
Primary completion: 2020
Study completion: 2020
First posted: Oct 16, 2015
Registry last updated: Apr 7, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed