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Completed

NCT Number: NCT00890071

Brachial Artery Peak Velocity Variation to Predict Fluid Responsiveness

The investigators designed this study to determine the predictive value for predicting fluid responsiveness of noninvasive evaluation of respiratory variation of peak velocity in brachial artery, in mechanically ventilated patients with acute circulatory failure.

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Key information

Conditions

Hypotension Cardiovascular Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Shock Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital del SAS de Jerez

Jerez de la Frontera, Cádiz, 11407, Spain

About this study

Predicting the hemodynamic response to fluid administration (or fluid responsiveness) in critical ill patients is still a matter of concern, since fluid overload could worse the clinical situation of these patients. Parameters of fluid responsiveness usually require an invasive monitoring (like arterial pulse pressure variation).

We hypothesize that noninvasive evaluation of respiratory variation of peak velocity in brachial artery using Doppler ultrasound could provide a feasible estimation on fluid responsiveness in mechanically ventilated patients with acute circulatory failure.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with controlled mechanical ventilation, equipped with an indwelling radial artery catheter and for whom the decision to give fluids will be taken because the presence of one or more clinical signs of acute circulatory failure:
  • systolic blood pressure <90 mmHg (or a decrease >50 mmHg in previously hypertensive patients)
  • the need of vasopressor drugs
  • oliguria (urine output <0.5 ml/kg/min for at least 2 h)
  • tachycardia
  • delayed capillary refilling
  • the presence of skin mottling

Exclusion criteria

  • Contraindication for the volume administration: evidence of fluid overload and/or of hydrostatic pulmonary edema
  • Patients with instable cardiac rhythm

Treatment and study plan

Fluid Administration

Other

500 ml of synthetic colloid (Voluven®, hydroxyethylstarch 6%; Fresenius, Bad Homburg, Germany) infused over 30 minutes

Primary outcomes

  1. Predictive value of respiratory variation in brachial artery peak velocity before volume expansion assessed by ROC curve. We defined responser as patients that increased stroke volume index equal or more than 15% after fluid administration.

    Time frame: immediately after volume expansion

Secondary outcomes

  1. Evaluate the predictive value of pulse pressure variation for predicting hemodynamic response to fluid administration, comparing with the predictive value of respiratory variation of brachial artery peak velocity.

    Time frame: immediately after fluid administration

  2. Evaluate the predictive value of stroke volume variation for predicting hemodynamic response to fluid administration, comparing with the predictive value of respiratory variation of brachial artery peak velocity.

    Time frame: immediately after volume expansion

Sponsors and collaborators

Lead sponsor

Hospital del SAS de Jerez

Other

Registry information

Official study title

Brachial Artery Peak Velocity Variation to Predict Fluid Responsiveness in Mechanically Ventilated Patients

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Apr 29, 2009
Registry last updated
Apr 29, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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