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NCT Number: NCT07256717

BPIT 5-Week Multi-Site Study: Movement Efficiency, Mobility & Neuromuscular Adaptation

This prospective, multi-site, single-arm interventional study evaluates the 5-Line Principle of Balanced Progressive Intensity Training (BPIT) over 5 weeks in healthy adults aged 18-65 years. All participants receive supervised BPIT sessions (3-5 per week) progressing through five intensity lines defined by anatomical landmarks and ground reaction force:

Ground-Based (Low) Knee-Level (Low-Moderate) Standing (Moderate) Head-Level (Moderate-High) Plyometric (High-Impact)

The study aims to quantify improvements in functional movement efficiency, joint mobility, postural control, strength adaptation, and heart-rate variability while monitoring safety and individual overload indicators.

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Key information

Conditions

Physical Fitness

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Indian Institute of Kinesiology & Biomechanics Science (IIKBS), Burhānpur, Madhya Pradesh, India

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About this study

Primary Outcome Measures

Change in Functional Movement Screen (FMS) total score from baseline to Week 5 Change in Y-Balance Test reach distance (composite score) Timeframe: Baseline and Week 5

Secondary Outcome Measures

Change in 1-RM or estimated strength (squat, deadlift, overhead press) Change in resting HRV (RMSSD) Change in joint range of motion (goniometry) and postural sway Incidence of training-related discomfort or minor injury Timeframe: Baseline, weekly, and Week 5

Arms/Intervention Experimental: BPIT 5-Line Training Group Intervention: Behavioral: Balanced Progressive Intensity Training (BPIT) 5-Line Method Description: 5-week supervised progressive training using the BPIT 5-Line framework (ground-based → plyometric) Eligibility

Ages Eligible: 18 Years to 65 Years Sexes Eligible: All Accepts Healthy Volunteers: Yes

Inclusion criteria

Healthy adults with regular exercise history Able to attend 3-5 training sessions/week Signed informed consent

Exclusion criteria

Recent injury (<3 months) Known cardiovascular, metabolic, or orthopaedic contraindications Pregnancy

Study Locations 13 Locations in India 2 Locations in USA, (Details of the location is uploaded on mmsxauthority.com webiste)

MMSx Authority , USA, GFFI Fitness Academy, New Delhi BodyGNTX USA BFS/AIHFT-approved facilities

Countries of Recruitment India U.S. FDA-regulated? No / No / No Human Subjects Protection Review Board Status Approved (or Submit for review if not yet) Board Name: Institutional Ethics Committee - MMSx Authority / GFFI Approval Number: BPIT-MULTI-2025-001 (or pending) Data Monitoring Committee No

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-65 years Generally healthy with regular physical activity history (at least 1-2 sessions per week for the past 3 months) Able to commit to 3-5 supervised training sessions per week for 5 weeks Willing and able to provide written informed consent Cleared by pre-screening (no acute injury, no contraindications)

Exclusion criteria

  • Acute musculoskeletal injury within the past 3 months Known cardiovascular, metabolic, or orthopaedic conditions that contraindicate exercise Pregnancy or planning pregnancy Use of medications or supplements that significantly affect muscle recovery or performance (e.g., corticosteroids, anabolic agents) Inability to follow the BPIT protocol or attend required sessions

Treatment and study plan

Balanced Progressive Intensity Training (BPIT) 5-Line Method

Behavioral

5-week supervised progressive training using the BPIT 5-Line framework developed by Dr. Neeraj Mehta.

Primary outcomes

  1. Movement Efficiency Score (MES, 0-10)

    Time frame: Baseline (Week 0) and end of study (Week 5)

    Change from baseline in the proprietary Movement Efficiency Score (MES), a validated composite metric of biomechanical function, movement quality, and postural alignment (derived from MMSx Flaw Checklist, visual/video analysis, and functional mapping).

Secondary outcomes

  1. Range of Motion (ROM)

    Time frame: Baseline and Week 5

    Change from baseline in joint range of motion (degrees) measured by goniometry at key sites (shoulder, hip, spine, ankle).

  2. VAS Pain Score

    Time frame: Baseline and Week 5

    Change from baseline in participant-reported pain/discomfort on a 0-10 Visual Analog Scale.

  3. Strength Index

    Time frame: Baseline and Week 5

    Change from baseline in Strength Index calculated as Reps × Load (or estimated 1RM where applicable) for key movements.

  4. Mobility Limitation (%)

    Time frame: Baseline and Week 5

    Change from baseline in self-reported percentage limitation in daily functional tasks due to mobility restrictions.

Other outcomes

  1. Heart Rate Variability (HRV - RMSSD)

    Time frame: Baseline and Week 5

    Change from baseline in resting heart rate variability (RMSSD) as a biomarker of autonomic recovery.

Sponsors and collaborators

Lead sponsor

MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.

Other

Collaborators

  • Active India Health & Fitness Trust (AIHFT)
  • Body Mechanic Chain of Gyms
  • BodyGNTX Fitness Institute
  • Bureau of Fitness Standards (BFS)
  • GFFI Fitness Academy
  • Indian Institute of Kinesiology and Biomechanics Science (IIKBS)
  • MMSx Authority Biomechanics Department
  • Regain Fitness Zone
  • Shri Mahaveer Ortho Clinic

Registry information

Official study title

Balanced Progressive Intensity Training (BPIT): A Five-Week Multi-Site Clinical Evaluation of Functional Movement, Mobility, and Neuromuscular Adaptation in Healthy Adults (18-65 Years)

Acronym: BPIT_5LINE_369

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 1, 2025
Registry last updated
Dec 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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