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NCT Number: NCT06903975

BoTox Into the Sternocleidomastoid Muscles (SCM)

Botulinum toxin injections have been used both in the face and neck for many years. However, injection into the sternocleidomastoid muscle (SCM) has only been done to treat neck spasms. In this study botulinum toxin will be injected into the SCM to determine if this will result in a temporary slimming effect on the neck and produce a more feminine, youthful neck contour.

Recruiting

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Key information

Conditions

Neck Muscle Issue

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

The Spiegel Center

Newton, Massachusetts, 02459, United States

Location status: Recruiting

Location contact

Amanda Goslawski, MD

CONTACT

[email protected]

Jeffrey Spiegel, MD

CONTACT

[email protected]

About this study

The specific study objectives are to determine if:

  • the neck circumference is decreased at 4 weeks after botulinum toxin (prabotulinumtoxinA-xvfs) injection.
  • patients can appreciate a difference in their neck contour, self-confidence, and the way they perceive themselves post-injection via an aesthetics outcome and a neck perception survey.
  • injection of the botulinum toxin into the sternocleidomastoid muscle is safe to perform based on adverse events.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age eligible individual seeking a more feminine neck appearance

Exclusion criteria

  • Prior neuromodulator injections in the sternocleidomastoid muscles (SCM) within the past year
  • Current anticoagulant use
  • Body mass index (BMI) >30
  • Anticipation of significant weight gain or loss during the study period (e.g. patients taking or planning to take within the study period a semaglutide medication.)
  • Prior allergy to botulinum toxin A
  • Currently pregnant or breastfeeding

Treatment and study plan

prabotulinumtoxinA-xvfs

Drug

Each participant will receive 60 units (U) of prabotulinumtoxinA-xvfs into each SCM for a total of 120 U. Participants will return in 2 weeks to determine if any touch-up injection is needed.

Other names: Jeuveau

Primary outcomes

  1. Neck circumference

    Time frame: Baseline, 4 weeks

    A standard tape measure will be used and circumference recorded in centimeters

Secondary outcomes

  1. Post injection neck appearance

    Time frame: 4 weeks

    A 5-item investigator developed questionnaire will be used to assess each participant's opinion about their neck appearance after the botulinum toxin injections. Each item has 4 potential responses from 1=Definitely disagree to 4=Definitely agree. Total scores can range from 5 to 20 and higher scores suggest more positive opinions about their neck appearance.

Study contacts

Contact information is provided by the study sponsor or research team.

Amanda Goslawski, MD

CONTACT

[email protected]

617 638-7934

Jeffrey Spiegel, MD

CONTACT

[email protected]

617 566-3223

Sponsors and collaborators

Lead sponsor

Boston Medical Center

Other

Collaborators

  • Evolus, Inc.

Registry information

Official study title

The Effect of Injection of prabotulinumtoxinA-xvfs (Jeuveau) Into the Bilateral Sternocleidomastoid Muscles on Neck Circumference and Aesthetics

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Apr 1, 2025
Registry last updated
Apr 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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