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NCT Number: NCT03228875

Boston Birth Cohort Study

Early life exposures may lead to adverse effects on health in later life. The Boston birth Cohort study is designed to study a broad array of early life factors and their effects on maternal and child health outcomes.

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Key information

Conditions

Maternal Health Birth Outcome, Adverse Child Health Disease Female Urogenital Diseases and Pregnancy Complications Pathologic Processes Pathological Conditions, Signs and Symptoms Pregnancy Complications Urogenital Diseases

Age range

0 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Boston Medical Center

Boston, Massachusetts, 02118, United States

Location status: Recruiting

Location contact

Colleen Pearson, BA

CONTACT

[email protected]

617-414-5133

About this study

Any woman admitted to the Labor and Delivery floor at the Boston Medical Center (BMC) who delivers a singleton live infant and meets our case (gestational age <37 weeks or birthweight <2,500 grams) or control (full term birth with birthweight >2,500 grams) criteria will be eligible.

Postnatal follow-up of enrolled mother-child pair is conducted from birth to age 21 years.

The Boston Birth Cohort has high-quality biospecimen collection, and comprehensive epidemiological, clinical, and environmental exposure data via standardized questionnaire interview, measurements, and review of the electronic medical records.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Mothers who deliver singleton live births at Boston Medical Center are eligible for the study.

Exclusion criteria

  • pregnancies that are a result of in vitro fertilization or that involve multiple gestations, fetal chromosomal abnormalities or major birth defects.

Treatment and study plan

Primary outcomes

  1. Pregnancy complications

    Time frame: At birth

    Multiple pregnancy complications are examined including gestational diabetes, hypertensive disorders of pregnancy.

  2. Birth outcomes - preterm birth

    Time frame: At birth

    Birth outcomes are examined - preterm birth.

  3. Birth outcomes - birthweight

    Time frame: At birth

    Birth outcomes are examined - birthweight.

  4. Child health outcomes

    Time frame: From birth to 21 years

    Multiple child health outcomes are examined including food allergy, asthma, child's overweight or obesity, blood pressure, and child neuro-developmental outcomes.

  5. Maternal health outcomes

    Time frame: After delivery to 21 years

    Multiple maternal health outcomes are measured including blood pressure, weight, height, physician diagnosis.

Study contacts

Contact information is provided by the study sponsor or research team.

Xiaobin Wang, MD, ScD

CONTACT

[email protected]

410-9555824

Sponsors and collaborators

Lead sponsor

Johns Hopkins Bloomberg School of Public Health

Other

Collaborators

  • Boston Medical Center
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Registry information

Official study title

Early Life Origins of Pediatric and Adult Diseases: Boston Birth Cohort Study

Important dates

Study start
1998
Primary completion
2028
Study completion
2028
First posted
Jul 25, 2017
Registry last updated
Sep 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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